The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses

N6-methyladenosine (m(6)A) is the most prevalent modification of mammalian cellular RNAs. m(6)A methylation is linked to epigenetic regulation of several aspects of gene expression, including RNA stability, splicing, nuclear export, RNA folding, and translational activity. m(6)A modification is reve...

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Autores principales: Kim, Geon-Woo, Siddiqui, Aleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080661/
https://www.ncbi.nlm.nih.gov/pubmed/33742132
http://dx.doi.org/10.1038/s12276-021-00581-3
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author Kim, Geon-Woo
Siddiqui, Aleem
author_facet Kim, Geon-Woo
Siddiqui, Aleem
author_sort Kim, Geon-Woo
collection PubMed
description N6-methyladenosine (m(6)A) is the most prevalent modification of mammalian cellular RNAs. m(6)A methylation is linked to epigenetic regulation of several aspects of gene expression, including RNA stability, splicing, nuclear export, RNA folding, and translational activity. m(6)A modification is reversibly catalyzed by methyltransferases (m(6)A writers) and demethylases (m(6)A erasers), and the dynamics of m(6)A-modified RNA are regulated by m(6)A-binding proteins (m(6)A readers). Recently, several studies have shown that m(6)A methylation sites have been identified in hepatitis B virus (HBV) transcripts and the hepatitis C virus (HCV) RNA genome. Here, we review the role of m(6)A modification in HBV/HCV replication and its contribution to liver disease pathogenesis. A better understanding of the functions of m(6)A methylation in the life cycles of HBV and HCV is required to establish the role of these modifications in liver diseases associated with these viral infections.
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spelling pubmed-80806612021-04-29 The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses Kim, Geon-Woo Siddiqui, Aleem Exp Mol Med Review Article N6-methyladenosine (m(6)A) is the most prevalent modification of mammalian cellular RNAs. m(6)A methylation is linked to epigenetic regulation of several aspects of gene expression, including RNA stability, splicing, nuclear export, RNA folding, and translational activity. m(6)A modification is reversibly catalyzed by methyltransferases (m(6)A writers) and demethylases (m(6)A erasers), and the dynamics of m(6)A-modified RNA are regulated by m(6)A-binding proteins (m(6)A readers). Recently, several studies have shown that m(6)A methylation sites have been identified in hepatitis B virus (HBV) transcripts and the hepatitis C virus (HCV) RNA genome. Here, we review the role of m(6)A modification in HBV/HCV replication and its contribution to liver disease pathogenesis. A better understanding of the functions of m(6)A methylation in the life cycles of HBV and HCV is required to establish the role of these modifications in liver diseases associated with these viral infections. Nature Publishing Group UK 2021-03-19 /pmc/articles/PMC8080661/ /pubmed/33742132 http://dx.doi.org/10.1038/s12276-021-00581-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kim, Geon-Woo
Siddiqui, Aleem
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title_full The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title_fullStr The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title_full_unstemmed The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title_short The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses
title_sort role of n6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis b and c viruses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080661/
https://www.ncbi.nlm.nih.gov/pubmed/33742132
http://dx.doi.org/10.1038/s12276-021-00581-3
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