Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells

Histidine triad nucleotide-binding protein 1 (HINT1), which belongs to the evolutionarily conserved HIT superfamily, has been shown to possess a tumor-suppressive function by binding to and inhibiting several oncogenic transcription factors, such as β-catenin and microphthalmia transcription factor...

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Detalles Bibliográficos
Autores principales: Jung, Taek-Yeol, Jin, Gyu-Rin, Koo, Young-Bin, Jang, Mi-Mi, Kim, Chan-Woo, Lee, Soh-Yeon, Kim, Hyelee, Lee, Chae-Young, Lee, Soo-Young, Ju, Bong-Gun, Kim, Hyun-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080686/
https://www.ncbi.nlm.nih.gov/pubmed/32636443
http://dx.doi.org/10.1038/s12276-020-0465-2

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