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Methotrexate reduces circulating Th17 cells and impairs plasmablast and memory B cell expansions following pneumococcal conjugate immunization in RA patients

Methotrexate (MTX) impairs antibody response after pneumococcal vaccination. We aimed to investigate differences in phenotypes of circulating B and T cells after pneumococcal conjugate vaccine (PCV) in rheumatoid arthritis (RA) patients on MTX (MTX group), RA without disease-modifying drugs (0DMARD)...

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Detalles Bibliográficos
Autores principales:	Nived, Per, Pettersson, Åsa, Jönsson, Göran, Bengtsson, Anders A., Settergren, Bo, Skattum, Lillemor, Johansson, Åsa, Kapetanovic, Meliha C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080705/ https://www.ncbi.nlm.nih.gov/pubmed/33911135 http://dx.doi.org/10.1038/s41598-021-88491-2

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