Cargando…

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction

The AHNAK nucleoprotein has been determined to exert an anti-obesity effect in adipose tissue and further inhibit adipogenic differentiation. In this study, we examined the role of AHNAK in regulating hepatic lipid metabolism to prevent diet-induced fatty liver. Ahnak KO mice have reportedly exhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yo Na, Shin, Jae Hoon, Kyeong, Dong Soo, Cho, Soo Young, Kim, Mi-Young, Lim, Hee Jung, Jimenez, Maria Raquel Rojas, Kim, Il Yong, Lee, Mi-Ock, Bae, Yun Soo, Seong, Je Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080712/ https://www.ncbi.nlm.nih.gov/pubmed/33785868 http://dx.doi.org/10.1038/s12276-021-00573-3

Ejemplares similares

AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
por: Shin, Jae Hoon, et al.
Publicado: (2016)

Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak (-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
por: Shin, Jae Hoon, et al.
Publicado: (2015)

Correction: Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak (-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
por: Shin, Jae Hoon, et al.
Publicado: (2015)

Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression
por: Woo, Jong Kyu, et al.
Publicado: (2018)

Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway
por: Yang, Insook, et al.
Publicado: (2022)

Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system
por: Lee, Jong-Min, et al.
Publicado: (2023)

Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition
por: Sohn, Mira, et al.
Publicado: (2018)

Ahnak-knockout mice show susceptibility to Bartonella henselae infection because of CD4+ T cell inactivation and decreased cytokine secretion
por: Choi, Eun Wha, et al.
Publicado: (2019)

The Obscure Potential of AHNAK2
por: Zardab, Mohamed, et al.
Publicado: (2022)

Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression
por: Kim, Hye Young, et al.
Publicado: (2022)

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells
por: Suh, Jung Min, et al.
Publicado: (2021)

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21
por: Kim, Eun Kyung, et al.
Publicado: (2016)

Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway
por: Lee, I H, et al.
Publicado: (2014)

AHNAKs roles in physiology and malignant tumors
por: Zhang, Shusen, et al.
Publicado: (2023)

AHNAK2 is a biomarker and a potential therapeutic target of adenocarcinomas: AHNAK2 is a biomarker for adenocarcinomas
por: Xu, Meng, et al.
Publicado: (2022)

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency
por: Jung, Ye-Eun, et al.
Publicado: (2023)

Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
por: Min, Byong-Keol, et al.
Publicado: (2019)

Antifungal Action of Arabidopsis thaliana TCP21 via Induction of Oxidative Stress and Apoptosis
por: Park, Seong-Cheol, et al.
Publicado: (2023)

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
por: Kim, Kook Hwan, et al.
Publicado: (2013)

Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
por: Kang, Myung-Ji, et al.
Publicado: (2019)

FGF8 is Essential for Functionality of Induced Neural Precursor Cell-derived Dopaminergic Neurons
por: Lim, Mi-Sun, et al.
Publicado: (2015)

Serum levels of FGF21 are reduced and negatively correlated with adiponectin in children with Prader-Willi syndrome
por: Kim, Su Jin, et al.
Publicado: (2013)

SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice
por: Lee, Bonggi, et al.
Publicado: (2022)

Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2
por: Moon, Hanbyeol, et al.
Publicado: (2022)

Effect of Instant Cooked Giant Embryonic Rice on Body Fat Weight and Plasma Lipid Profile in High Fat-Fed Mice
por: Chung, Soo Im, et al.
Publicado: (2014)

Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
por: Kim, Eun-Kyung, et al.
Publicado: (2018)

A portable inhalational induction device provides co-operative induction of anaesthesia in preanaesthetic area for children
por: Yun, Mi-Ja, et al.
Publicado: (2010)

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
por: Kim, Kook Hwan, et al.
Publicado: (2014)

Relationship Between the Serum FGF21 Level and Growth in Children of Short Stature
por: Lee, Yun Jeong, et al.
Publicado: (2023)

Age‐related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression
por: Mahmoodzadeh, Shokoufeh, et al.
Publicado: (2021)

Modulatory Effect of Rice Bran and Phytic Acid on Glucose Metabolism in High Fat-Fed C57BL/6N Mice
por: Kim, Soo Mi, et al.
Publicado: (2010)

Comparative Evaluation between Sulfasalazine Alone and in Combination with Herbal Medicine on DSS-Induced Ulcerative Colitis Mice
por: Shin, Mi-Rae, et al.
Publicado: (2017)

Protaetia brevitarsis Extract Attenuates RANKL-Induced Osteoclastogenesis by Inhibiting the JNK/NF-κB/PLCγ2 Signaling Pathway
por: Jang, Hye-Yeon, et al.
Publicado: (2023)

Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
por: Yoon, Kyoung B., et al.
Publicado: (2016)

Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction
por: Kim, Il Young, et al.
Publicado: (2020)

A Study on Dietary Habits and Lifestyle of Girls with Precocious Puberty
por: Heo, Jae-Seong, et al.
Publicado: (2016)

Linolenic Acid Attenuates the Vasodilation Induced by Acetylcholine in Isolated Rat Aortae
por: Lee, Soo Hee, et al.
Publicado: (2019)

AHNAK and Inflammatory Markers Predict Poor Survival in Laryngeal Carcinoma
por: Dumitru, Claudia A., et al.
Publicado: (2013)

AHNAK as a Prognosis Factor Suppresses the Tumor Progression in Glioma
por: Zhao, Zijin, et al.
Publicado: (2017)

AHNAK2 is a potential prognostic biomarker in patients with PDAC
por: Lu, Di, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hc2ur1er602sqs2rokdihhnngu