A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells

Peroxisome proliferator-activated receptor gamma (PPARɣ) agonists exert powerful anticancer effects by suppressing tumor growth. In this study, we developed PPZ023 (1-(2-(ethylthio)benzyl)-4-(2-methoxyphenyl)piperazine), a novel PPAR ligand candidate, and investigated the underlying signaling pathwa...

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Detalles Bibliográficos
Autores principales: Kim, Tae Woo, Hong, Da-Won, Kang, Chang-Mo, Hong, Sung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080717/
https://www.ncbi.nlm.nih.gov/pubmed/33046822
http://dx.doi.org/10.1038/s12276-020-00511-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080717/
https://www.ncbi.nlm.nih.gov/pubmed/33046822
http://dx.doi.org/10.1038/s12276-020-00511-9

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