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Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoid malignancy and a highly heterogeneous disease. In this study, we performed whole-genome and transcriptome sequencing, and a genome-wide CRISPR-Cas9-knockout screen to study an activated B-cell-like DLBCL cell line (...

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Detalles Bibliográficos
Autores principales:	Nie, Man, Du, Likun, Ren, Weicheng, Joung, Julia, Ye, Xiaofei, Shi, Xi, Ciftci, Sibel, Liu, Dongbing, Wu, Kui, Zhang, Feng, Pan-Hammarström, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080727/ https://www.ncbi.nlm.nih.gov/pubmed/33911074 http://dx.doi.org/10.1038/s41419-021-03695-8

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