Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists

Although several potent bile acid Farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5, GPBAR1) dual agonists such as INT-767 have been reported, no non-bile acid FXR/TGR5 dual agonist has been investigated to date. Therefore, we attempted to discover potent non-bile acid FXR/TGR...

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Detalles Bibliográficos
Autores principales: Miyata, Sachiho, Kawashima, Yuji, Sakai, Miku, Matsubayashi, Masaya, Motoki, Keisuke, Miyajima, Yui, Watanabe, Yousuke, Chikamatsu, Noriko, Taniguchi, Tetsuya, Tokuyama, Ryukou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080777/
https://www.ncbi.nlm.nih.gov/pubmed/33911126
http://dx.doi.org/10.1038/s41598-021-88493-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080777/
https://www.ncbi.nlm.nih.gov/pubmed/33911126
http://dx.doi.org/10.1038/s41598-021-88493-0

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