A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy

Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV...

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Autores principales: Denha, Eric, Rahim, Ali, Modi, Sunjay, Oyibo, Oghenekpaobor, Scott, Megan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080951/
https://www.ncbi.nlm.nih.gov/pubmed/33936877
http://dx.doi.org/10.7759/cureus.14165
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author Denha, Eric
Rahim, Ali
Modi, Sunjay
Oyibo, Oghenekpaobor
Scott, Megan
author_facet Denha, Eric
Rahim, Ali
Modi, Sunjay
Oyibo, Oghenekpaobor
Scott, Megan
author_sort Denha, Eric
collection PubMed
description Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. A 55-year-old male with decompensated alcoholic cirrhosis presented for a bilateral lower-extremity rash. The patient was diagnosed with IgA nephropathy, by kidney biopsy, and skin biopsy showing LCV. Further investigation revealed hepatitis C viral load was 275,000. We present a rare presentation of secondary IgA nephropathy with concomitant LCV, which we hypothesize was secondary to reactivation of hepatitis C.
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spelling pubmed-80809512021-04-29 A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy Denha, Eric Rahim, Ali Modi, Sunjay Oyibo, Oghenekpaobor Scott, Megan Cureus Internal Medicine Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. A 55-year-old male with decompensated alcoholic cirrhosis presented for a bilateral lower-extremity rash. The patient was diagnosed with IgA nephropathy, by kidney biopsy, and skin biopsy showing LCV. Further investigation revealed hepatitis C viral load was 275,000. We present a rare presentation of secondary IgA nephropathy with concomitant LCV, which we hypothesize was secondary to reactivation of hepatitis C. Cureus 2021-03-29 /pmc/articles/PMC8080951/ /pubmed/33936877 http://dx.doi.org/10.7759/cureus.14165 Text en Copyright © 2021, Denha et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Denha, Eric
Rahim, Ali
Modi, Sunjay
Oyibo, Oghenekpaobor
Scott, Megan
A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title_full A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title_fullStr A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title_full_unstemmed A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title_short A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy
title_sort 55-year-old male presenting with a lower extremity rash: a case of immunoglobulin a (iga) nephropathy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080951/
https://www.ncbi.nlm.nih.gov/pubmed/33936877
http://dx.doi.org/10.7759/cureus.14165
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