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NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting
Antigen stimulation (signal 1) triggers B cell proliferation, and primes B cells to recruit, engage, and respond to T cell help (signal 2). Failure to receive signal 2 within a defined time window results in B cell apoptosis, yet the mechanisms that enforce dependence upon co-stimulation are incompl...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081071/ https://www.ncbi.nlm.nih.gov/pubmed/32868928 http://dx.doi.org/10.1038/s41590-020-0765-7 |