The RNA helicase DDX5 promotes viral infection via regulating N(6)-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity

Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional regulation, is hijacked by diverse viruses to facilitate viral replication. However, its regulatory effect in antiviral innate immunity remains unclear. We found that DDX5 interacts with the N(6)-methyladenosine (m6A)...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Cai, Yunhong, Ma, ZhenBang, Jiang, Bo, Liu, Wenxiao, Cheng, Jing, Guo, Nannan, Wang, Zishu, Sealy, Joshua E., Song, Cuiping, Wang, Xiaojia, Li, Yongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081163/
https://www.ncbi.nlm.nih.gov/pubmed/33909701
http://dx.doi.org/10.1371/journal.ppat.1009530

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