Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy

Metabolism is a common cellular feature. Cancer creates a suppressive microenvironment resulting in inactivation of antigen-specific T cells by metabolic reprogramming. Development of approaches that enhance and sustain physiologic properties of T cell metabolism to prevent T cell inactivation and p...

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Detalles Bibliográficos
Autores principales: Christofides, Anthos, Tijaro-Ovalle, Natalia M., Boussiotis, Vassiliki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081294/
https://www.ncbi.nlm.nih.gov/pubmed/33927895
http://dx.doi.org/10.20900/immunometab20210016
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author Christofides, Anthos
Tijaro-Ovalle, Natalia M.
Boussiotis, Vassiliki A.
author_facet Christofides, Anthos
Tijaro-Ovalle, Natalia M.
Boussiotis, Vassiliki A.
author_sort Christofides, Anthos
collection PubMed
description Metabolism is a common cellular feature. Cancer creates a suppressive microenvironment resulting in inactivation of antigen-specific T cells by metabolic reprogramming. Development of approaches that enhance and sustain physiologic properties of T cell metabolism to prevent T cell inactivation and promote effector function in the tumor microenvironment is an urgent need for improvement of cell-based cancer immunotherapies.
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spelling pubmed-80812942021-04-28 Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy Christofides, Anthos Tijaro-Ovalle, Natalia M. Boussiotis, Vassiliki A. Immunometabolism Article Metabolism is a common cellular feature. Cancer creates a suppressive microenvironment resulting in inactivation of antigen-specific T cells by metabolic reprogramming. Development of approaches that enhance and sustain physiologic properties of T cell metabolism to prevent T cell inactivation and promote effector function in the tumor microenvironment is an urgent need for improvement of cell-based cancer immunotherapies. 2021 /pmc/articles/PMC8081294/ /pubmed/33927895 http://dx.doi.org/10.20900/immunometab20210016 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Christofides, Anthos
Tijaro-Ovalle, Natalia M.
Boussiotis, Vassiliki A.
Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title_full Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title_fullStr Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title_full_unstemmed Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title_short Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy
title_sort commentary on: combination of metabolic intervention and t cell therapy enhances solid tumor immunotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081294/
https://www.ncbi.nlm.nih.gov/pubmed/33927895
http://dx.doi.org/10.20900/immunometab20210016
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