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The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery

Whole cell-based phenotypic screens have become the primary mode of hit generation in tuberculosis (TB) drug discovery during the last two decades. Different drug screening models have been developed to mirror the complexity of TB disease in the laboratory. As these culture conditions are becoming m...

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Detalles Bibliográficos
Autores principales: Yuan, Tianao, Werman, Joshua M., Sampson, Nicole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081351/
https://www.ncbi.nlm.nih.gov/pubmed/33928253
http://dx.doi.org/10.1039/d0cb00226g