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Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience

Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literat...

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Autores principales: Swed, Brandon, Gandarilla, Omar, Chiu, Kenrry, Halazun, Karim H., Samstein, Benjamin, Yantiss, Rhonda, Brar, Gagandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081640/
https://www.ncbi.nlm.nih.gov/pubmed/33968454
http://dx.doi.org/10.1155/2021/6654229
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author Swed, Brandon
Gandarilla, Omar
Chiu, Kenrry
Halazun, Karim H.
Samstein, Benjamin
Yantiss, Rhonda
Brar, Gagandeep
author_facet Swed, Brandon
Gandarilla, Omar
Chiu, Kenrry
Halazun, Karim H.
Samstein, Benjamin
Yantiss, Rhonda
Brar, Gagandeep
author_sort Swed, Brandon
collection PubMed
description Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literature regarding the nonsurgical management of these patients upon disease recurrence remains limited. These variants include combined HCC-cholangiocarcinoma (cHCC-CC), Epstein–Barr virus- (EBV-) associated carcinoma, undifferentiated carcinoma, and clear cell or thyroid-like variants of HCC. Here, we aim to highlight the pathologic features, clinical course, and outcomes of five patients with these unusual hepatic tumors and explain the rationale behind the choice of their systemic therapies upon disease recurrence. All patients underwent surgical resection as the standard of care for localized disease, and upon relapse, they were treated with either chemotherapy, targeted therapy, immunotherapy, or active surveillance based on the clinical context and tumor histology. These rare variants are important to recognize as they have prognostic and therapeutic implications, and there are currently insufficient data in the literature to guide further therapy.
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spelling pubmed-80816402021-05-06 Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience Swed, Brandon Gandarilla, Omar Chiu, Kenrry Halazun, Karim H. Samstein, Benjamin Yantiss, Rhonda Brar, Gagandeep Case Reports Hepatol Case Series Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literature regarding the nonsurgical management of these patients upon disease recurrence remains limited. These variants include combined HCC-cholangiocarcinoma (cHCC-CC), Epstein–Barr virus- (EBV-) associated carcinoma, undifferentiated carcinoma, and clear cell or thyroid-like variants of HCC. Here, we aim to highlight the pathologic features, clinical course, and outcomes of five patients with these unusual hepatic tumors and explain the rationale behind the choice of their systemic therapies upon disease recurrence. All patients underwent surgical resection as the standard of care for localized disease, and upon relapse, they were treated with either chemotherapy, targeted therapy, immunotherapy, or active surveillance based on the clinical context and tumor histology. These rare variants are important to recognize as they have prognostic and therapeutic implications, and there are currently insufficient data in the literature to guide further therapy. Hindawi 2021-04-21 /pmc/articles/PMC8081640/ /pubmed/33968454 http://dx.doi.org/10.1155/2021/6654229 Text en Copyright © 2021 Brandon Swed et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Swed, Brandon
Gandarilla, Omar
Chiu, Kenrry
Halazun, Karim H.
Samstein, Benjamin
Yantiss, Rhonda
Brar, Gagandeep
Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title_full Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title_fullStr Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title_full_unstemmed Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title_short Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
title_sort rare histological variants of liver cancer and their management: a single-institution experience
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081640/
https://www.ncbi.nlm.nih.gov/pubmed/33968454
http://dx.doi.org/10.1155/2021/6654229
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