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Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience
Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081640/ https://www.ncbi.nlm.nih.gov/pubmed/33968454 http://dx.doi.org/10.1155/2021/6654229 |
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author | Swed, Brandon Gandarilla, Omar Chiu, Kenrry Halazun, Karim H. Samstein, Benjamin Yantiss, Rhonda Brar, Gagandeep |
author_facet | Swed, Brandon Gandarilla, Omar Chiu, Kenrry Halazun, Karim H. Samstein, Benjamin Yantiss, Rhonda Brar, Gagandeep |
author_sort | Swed, Brandon |
collection | PubMed |
description | Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literature regarding the nonsurgical management of these patients upon disease recurrence remains limited. These variants include combined HCC-cholangiocarcinoma (cHCC-CC), Epstein–Barr virus- (EBV-) associated carcinoma, undifferentiated carcinoma, and clear cell or thyroid-like variants of HCC. Here, we aim to highlight the pathologic features, clinical course, and outcomes of five patients with these unusual hepatic tumors and explain the rationale behind the choice of their systemic therapies upon disease recurrence. All patients underwent surgical resection as the standard of care for localized disease, and upon relapse, they were treated with either chemotherapy, targeted therapy, immunotherapy, or active surveillance based on the clinical context and tumor histology. These rare variants are important to recognize as they have prognostic and therapeutic implications, and there are currently insufficient data in the literature to guide further therapy. |
format | Online Article Text |
id | pubmed-8081640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80816402021-05-06 Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience Swed, Brandon Gandarilla, Omar Chiu, Kenrry Halazun, Karim H. Samstein, Benjamin Yantiss, Rhonda Brar, Gagandeep Case Reports Hepatol Case Series Primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma, are a major cause of cancer-related morbidity and mortality worldwide. There are several histologically and biologically distinct subtypes of liver cancer that have previously been reported. However, literature regarding the nonsurgical management of these patients upon disease recurrence remains limited. These variants include combined HCC-cholangiocarcinoma (cHCC-CC), Epstein–Barr virus- (EBV-) associated carcinoma, undifferentiated carcinoma, and clear cell or thyroid-like variants of HCC. Here, we aim to highlight the pathologic features, clinical course, and outcomes of five patients with these unusual hepatic tumors and explain the rationale behind the choice of their systemic therapies upon disease recurrence. All patients underwent surgical resection as the standard of care for localized disease, and upon relapse, they were treated with either chemotherapy, targeted therapy, immunotherapy, or active surveillance based on the clinical context and tumor histology. These rare variants are important to recognize as they have prognostic and therapeutic implications, and there are currently insufficient data in the literature to guide further therapy. Hindawi 2021-04-21 /pmc/articles/PMC8081640/ /pubmed/33968454 http://dx.doi.org/10.1155/2021/6654229 Text en Copyright © 2021 Brandon Swed et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Series Swed, Brandon Gandarilla, Omar Chiu, Kenrry Halazun, Karim H. Samstein, Benjamin Yantiss, Rhonda Brar, Gagandeep Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title | Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title_full | Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title_fullStr | Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title_full_unstemmed | Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title_short | Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience |
title_sort | rare histological variants of liver cancer and their management: a single-institution experience |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081640/ https://www.ncbi.nlm.nih.gov/pubmed/33968454 http://dx.doi.org/10.1155/2021/6654229 |
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