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Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data

In the approval process for new weight management therapies, regulators typically require estimates of effect size. Usually, as with other drug evaluations, the placebo-adjusted treatment effect (i.e., the difference between weight losses with pharmacotherapy and placebo, when given as an adjunct to...

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Detalles Bibliográficos
Autores principales: Wharton, Sean, Astrup, Arne, Endahl, Lars, Lean, Michael E. J., Satylganova, Altynai, Skovgaard, Dorthe, Wadden, Thomas A., Wilding, John P. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081661/
https://www.ncbi.nlm.nih.gov/pubmed/33462358
http://dx.doi.org/10.1038/s41366-020-00733-x

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