Vaccination with (1–11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice

Immunization against β-amyloid (Aβ) is pursued as a possible strategy for the prevention of Alzheimer’s disease (AD). In clinical trials, Aβ 1–42 proved poorly immunogenic and caused severe adverse effects; therefore, safer and more immunogenic candidate vaccines are needed. Multimeric protein (1–11...

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Detalles Bibliográficos
Autores principales: Mantile, Francesca, Capasso, Angelo, Villacampa, Nadia, Donnini, Maria, Liguori, Giovanna L., Constantin, Gabriela, De Berardinis, Piergiuseppe, Heneka, Michael T., Prisco, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081683/
https://www.ncbi.nlm.nih.gov/pubmed/31758499
http://dx.doi.org/10.1007/s40520-019-01414-0

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