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Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis

In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also...

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Autores principales: Mandoli, Giulia Elena, D'Ascenzi, Flavio, Vinco, Giulia, Benfari, Giovanni, Ricci, Fabrizio, Focardi, Marta, Cavigli, Luna, Pastore, Maria Concetta, Sisti, Nicolò, De Vivo, Oreste, Santoro, Ciro, Mondillo, Sergio, Cameli, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081830/
https://www.ncbi.nlm.nih.gov/pubmed/33937354
http://dx.doi.org/10.3389/fcvm.2021.614235
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author Mandoli, Giulia Elena
D'Ascenzi, Flavio
Vinco, Giulia
Benfari, Giovanni
Ricci, Fabrizio
Focardi, Marta
Cavigli, Luna
Pastore, Maria Concetta
Sisti, Nicolò
De Vivo, Oreste
Santoro, Ciro
Mondillo, Sergio
Cameli, Matteo
author_facet Mandoli, Giulia Elena
D'Ascenzi, Flavio
Vinco, Giulia
Benfari, Giovanni
Ricci, Fabrizio
Focardi, Marta
Cavigli, Luna
Pastore, Maria Concetta
Sisti, Nicolò
De Vivo, Oreste
Santoro, Ciro
Mondillo, Sergio
Cameli, Matteo
author_sort Mandoli, Giulia Elena
collection PubMed
description In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yield and prognostic value of speckle tracking echocardiography, late gadolinium enhancement and parametric mapping modules by cardiac magnetic resonance and cardiac computed tomography have been validated against tissue samples and tested in broad patient populations, overall providing relevant clinical information to the cardiologist. This review describes the patterns of left ventricular and left atrial fibrosis, and their characterization by advanced echocardiography, cardiac magnetic resonance and cardiac computed tomography, allowing for clinical applications in sudden cardiac death and management of atrial fibrillation.
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spelling pubmed-80818302021-04-30 Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis Mandoli, Giulia Elena D'Ascenzi, Flavio Vinco, Giulia Benfari, Giovanni Ricci, Fabrizio Focardi, Marta Cavigli, Luna Pastore, Maria Concetta Sisti, Nicolò De Vivo, Oreste Santoro, Ciro Mondillo, Sergio Cameli, Matteo Front Cardiovasc Med Cardiovascular Medicine In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yield and prognostic value of speckle tracking echocardiography, late gadolinium enhancement and parametric mapping modules by cardiac magnetic resonance and cardiac computed tomography have been validated against tissue samples and tested in broad patient populations, overall providing relevant clinical information to the cardiologist. This review describes the patterns of left ventricular and left atrial fibrosis, and their characterization by advanced echocardiography, cardiac magnetic resonance and cardiac computed tomography, allowing for clinical applications in sudden cardiac death and management of atrial fibrillation. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8081830/ /pubmed/33937354 http://dx.doi.org/10.3389/fcvm.2021.614235 Text en Copyright © 2021 Mandoli, D'Ascenzi, Vinco, Benfari, Ricci, Focardi, Cavigli, Pastore, Sisti, De Vivo, Santoro, Mondillo and Cameli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Mandoli, Giulia Elena
D'Ascenzi, Flavio
Vinco, Giulia
Benfari, Giovanni
Ricci, Fabrizio
Focardi, Marta
Cavigli, Luna
Pastore, Maria Concetta
Sisti, Nicolò
De Vivo, Oreste
Santoro, Ciro
Mondillo, Sergio
Cameli, Matteo
Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title_full Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title_fullStr Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title_full_unstemmed Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title_short Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis
title_sort novel approaches in cardiac imaging for non-invasive assessment of left heart myocardial fibrosis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081830/
https://www.ncbi.nlm.nih.gov/pubmed/33937354
http://dx.doi.org/10.3389/fcvm.2021.614235
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