Cargando…

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular pathology of idiopathic and familial PD. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J., Connor-Robson, Natalie, Platt, Nicola J., Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J., Brimblecombe, Katherine R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081845/ https://www.ncbi.nlm.nih.gov/pubmed/33935654 http://dx.doi.org/10.3389/fncel.2021.658244

Ejemplares similares

Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors
por: Brimblecombe, Katherine R., et al.
Publicado: (2018)

Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons
por: Kosillo, Polina, et al.
Publicado: (2016)

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
por: Condon, Mark D., et al.
Publicado: (2019)

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
por: Roberts, Bradley M., et al.
Publicado: (2020)

Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice
por: Platt, Nicola J., et al.
Publicado: (2012)

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior
por: Hunn, Benjamin H.M., et al.
Publicado: (2019)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
por: Fields, Carroll Rutherford, et al.
Publicado: (2019)

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation
por: Jennings, Katie A., et al.
Publicado: (2015)

Alpha-synuclein oligomers: a new hope
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2017)

Dopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons
por: Threlfell, Sarah, et al.
Publicado: (2011)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

The Convergence of Dopamine and α-Synuclein: Implications for Parkinson’s Disease
por: Mor, Danielle E, et al.
Publicado: (2018)

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse()
por: Taylor, Tonya N., et al.
Publicado: (2014)

Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca(2+) Availability and Dopamine Transporter Function
por: Brimblecombe, Katherine R., et al.
Publicado: (2019)

Interaction of manganese with striatal dopamine turnover in human alpha-synuclein transgenic mice
por: Peneder, Tamara M, et al.
Publicado: (2010)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2023)

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function
por: Sloan, Max, et al.
Publicado: (2016)

Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling
por: Roberts, Bradley M., et al.
Publicado: (2021)

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
por: Kosillo, Polina, et al.
Publicado: (2019)

Inhibition of Nigrostriatal Dopamine Release by Striatal GABA(A) and GABA(B) Receptors
por: Lopes, Emanuel F., et al.
Publicado: (2019)

Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration
por: Pristerà, Alessandro, et al.
Publicado: (2019)

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse
por: Cahill, Emma, et al.
Publicado: (2014)

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
por: Caló, Laura, et al.
Publicado: (2021)

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
por: Kurz, Alexander, et al.
Publicado: (2010)

Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease
por: Ruffmann, C., et al.
Publicado: (2018)

Convergent cortical innervation of striatal projection neurons
por: Kress, Geraldine J., et al.
Publicado: (2013)

Local control of striatal dopamine release
por: Cachope, Roger, et al.
Publicado: (2014)

Abnormal Striatal Dopamine Transmission in Schizophrenia
por: Brunelin, Jerome, et al.
Publicado: (2013)

Striatal Dopamine Signals and Reward Learning
por: Bech, Pol, et al.
Publicado: (2023)

Deficits in striatal dopamine release in cannabis dependence
por: van de Giessen, Elsmarieke, et al.
Publicado: (2016)

On the normative advantages of dopamine and striatal opponency for learning and choice
por: Jaskir, Alana, et al.
Publicado: (2023)

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2020)

Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss
por: McFarland, Nikolaus R., et al.
Publicado: (2014)

Dopamine and glutamate regulate striatal acetylcholine in decision-making
por: Chantranupong, Lynne, et al.
Publicado: (2023)

Impaired dopamine release in Parkinson’s disease
por: Cramb, Kaitlyn M L, et al.
Publicado: (2023)

Dopamine regulation of striatal inhibitory transmission and plasticity: dopamine, low or high?
por: Hernández-Echeagaray, Elizabeth
Publicado: (2016)

Selective vulnerability in α-synucleinopathies
por: Alegre-Abarrategui, Javier, et al.
Publicado: (2019)

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles
por: Doucet, Marika, et al.
Publicado: (2017)

Haloperidol effects on striatal dopamine and DOPAC levels and subcellular distribution
por: Wallace, Lane J
Publicado: (2012)

Striatal Dopamine and the Interface between Motivation and Cognition
por: Aarts, Esther, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bqfecg5s14rioti07s3jobl4fe