Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia

Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes secreted by tumor play an important role in fat loss. However, there is no related reviews summar...

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Detalles Bibliográficos
Autores principales: Du, Guannan, Zhang, Yunan, Hu, Shoushan, Zhou, Xueer, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081875/
https://www.ncbi.nlm.nih.gov/pubmed/33997537
http://dx.doi.org/10.1016/j.ncrna.2021.04.001
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author Du, Guannan
Zhang, Yunan
Hu, Shoushan
Zhou, Xueer
Li, Yi
author_facet Du, Guannan
Zhang, Yunan
Hu, Shoushan
Zhou, Xueer
Li, Yi
author_sort Du, Guannan
collection PubMed
description Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes secreted by tumor play an important role in fat loss. However, there is no related reviews summarizing how ncRNAs contribute to fat loss during CC. This review screens recent articles to summarize how ncRNAs are packaged, transported in exosomes, and play the role in fat loss. Not only does this review summarize the mechanisms, we also point out the research orientations in the future.
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spelling pubmed-80818752021-05-13 Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia Du, Guannan Zhang, Yunan Hu, Shoushan Zhou, Xueer Li, Yi Noncoding RNA Res Article Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes secreted by tumor play an important role in fat loss. However, there is no related reviews summarizing how ncRNAs contribute to fat loss during CC. This review screens recent articles to summarize how ncRNAs are packaged, transported in exosomes, and play the role in fat loss. Not only does this review summarize the mechanisms, we also point out the research orientations in the future. KeAi Publishing 2021-04-15 /pmc/articles/PMC8081875/ /pubmed/33997537 http://dx.doi.org/10.1016/j.ncrna.2021.04.001 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Du, Guannan
Zhang, Yunan
Hu, Shoushan
Zhou, Xueer
Li, Yi
Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title_full Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title_fullStr Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title_full_unstemmed Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title_short Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
title_sort non-coding rnas in exosomes and adipocytes cause fat loss during cancer cachexia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081875/
https://www.ncbi.nlm.nih.gov/pubmed/33997537
http://dx.doi.org/10.1016/j.ncrna.2021.04.001
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