Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

The aggregation of amyloidogenic polypeptides is strongly linked to several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Conformational antibodies that selectively recognize protein aggregates are leading therapeutic agents for selectively neutralizing toxic aggregate...

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Detalles Bibliográficos
Autores principales: Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081927/
https://www.ncbi.nlm.nih.gov/pubmed/33675750
http://dx.doi.org/10.1016/j.jbc.2021.100508

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