N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

OBJECTIVE: Metabolic deregulation is a key hallmark of cancer cells and has been shown to drive cancer growth and metastasis. However, not all metabolic drivers of melanoma are known. Based on our finding that N-acylsphingosine amidohydrolase 1 (ASAH1) is overexpressed in melanoma, the objective of...

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Detalles Bibliográficos
Autores principales: Malvi, Parmanand, Janostiak, Radoslav, Nagarajan, Arvindhan, Zhang, Xuchen, Wajapeyee, Narendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081993/
https://www.ncbi.nlm.nih.gov/pubmed/33766731
http://dx.doi.org/10.1016/j.molmet.2021.101217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081993/
https://www.ncbi.nlm.nih.gov/pubmed/33766731
http://dx.doi.org/10.1016/j.molmet.2021.101217

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