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N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

OBJECTIVE: Metabolic deregulation is a key hallmark of cancer cells and has been shown to drive cancer growth and metastasis. However, not all metabolic drivers of melanoma are known. Based on our finding that N-acylsphingosine amidohydrolase 1 (ASAH1) is overexpressed in melanoma, the objective of...

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Detalles Bibliográficos
Autores principales:	Malvi, Parmanand, Janostiak, Radoslav, Nagarajan, Arvindhan, Zhang, Xuchen, Wajapeyee, Narendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081993/ https://www.ncbi.nlm.nih.gov/pubmed/33766731 http://dx.doi.org/10.1016/j.molmet.2021.101217

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