Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, the clinical efficacy of this novel therapy in solid tumor treatment is largely limited by the immunosuppressive tumor microenvironment (TME). For instance, immune checkpoints (e.g., p...

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Detalles Bibliográficos
Autores principales: Chen, Xianhui, Yang, Shuai, Li, Si, Qu, Yun, Wang, Hsuan-Yao, Liu, Jiangyue, Dunn, Zachary S., Cinay, Gunce E., MacMullan, Melanie A., Hu, Fangheng, Zhang, Xiaoyang, Wang, Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082048/
https://www.ncbi.nlm.nih.gov/pubmed/33981830
http://dx.doi.org/10.1016/j.omto.2021.03.014

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