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NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

Frameshifted protein sequences elicit tumor-specific T cell-mediated immune responses in microsatellite-unstable (MSI) cancers if presented by HLA class I molecules. However, their expression and presentation are limited by nonsense-mediated RNA decay (NMD). We employed an unbiased immunopeptidomics...

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Detalles Bibliográficos
Autores principales:	Becker, Jonas P., Helm, Dominic, Rettel, Mandy, Stein, Frank, Hernandez-Sanchez, Alejandro, Urban, Katharina, Gebert, Johannes, Kloor, Matthias, Neu-Yilik, Gabriele, von Knebel Doeberitz, Magnus, Hentze, Matthias W., Kulozik, Andreas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082087/ https://www.ncbi.nlm.nih.gov/pubmed/33981976 http://dx.doi.org/10.1016/j.isci.2021.102389

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