Machine learning workflows identify a microRNA signature of insulin transcription in human tissues

Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic β-cell function. Studies to identify specific microRNA(s) associated with human (pro-)endocrine gene expression are needed. We profiled microRNAs and key pancreatic genes in 353 human tissue samples. Machine learning wor...

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Detalles Bibliográficos
Autores principales: Wong, Wilson K.M., Joglekar, Mugdha V., Saini, Vijit, Jiang, Guozhi, Dong, Charlotte X., Chaitarvornkit, Alissa, Maciag, Grzegorz J., Gerace, Dario, Farr, Ryan J., Satoor, Sarang N., Sahu, Subhshri, Sharangdhar, Tejaswini, Ahmed, Asma S., Chew, Yi Vee, Liuwantara, David, Heng, Benjamin, Lim, Chai K., Hunter, Julie, Januszewski, Andrzej S., Sørensen, Anja E., Akil, Ammira S.A., Gamble, Jennifer R., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., O'Connell, Philip J., Guillemin, Gilles J., Martin, David, Simpson, Ann M., Hawthorne, Wayne J., Dalgaard, Louise T., Ma, Ronald C.W., Hardikar, Anandwardhan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082091/
https://www.ncbi.nlm.nih.gov/pubmed/33981968
http://dx.doi.org/10.1016/j.isci.2021.102379

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