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Advances of Regulatory B Cells in Autoimmune Diseases

With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive func...

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Detalles Bibliográficos
Autores principales: Zhu, Qiugang, Rui, Ke, Wang, Shengjun, Tian, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082147/
https://www.ncbi.nlm.nih.gov/pubmed/33936028
http://dx.doi.org/10.3389/fimmu.2021.592914
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author Zhu, Qiugang
Rui, Ke
Wang, Shengjun
Tian, Jie
author_facet Zhu, Qiugang
Rui, Ke
Wang, Shengjun
Tian, Jie
author_sort Zhu, Qiugang
collection PubMed
description With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive functions via diverse mechanisms, including the secretion of anti-inflammatory cytokines and direct cell contact. The balance between Bregs and effector B cells is important for the immune tolerance. In this review, we focus on recent advances in the characteristics of Bregs and their functional roles in autoimmunity.
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spelling pubmed-80821472021-04-30 Advances of Regulatory B Cells in Autoimmune Diseases Zhu, Qiugang Rui, Ke Wang, Shengjun Tian, Jie Front Immunol Immunology With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive functions via diverse mechanisms, including the secretion of anti-inflammatory cytokines and direct cell contact. The balance between Bregs and effector B cells is important for the immune tolerance. In this review, we focus on recent advances in the characteristics of Bregs and their functional roles in autoimmunity. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8082147/ /pubmed/33936028 http://dx.doi.org/10.3389/fimmu.2021.592914 Text en Copyright © 2021 Zhu, Rui, Wang and Tian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhu, Qiugang
Rui, Ke
Wang, Shengjun
Tian, Jie
Advances of Regulatory B Cells in Autoimmune Diseases
title Advances of Regulatory B Cells in Autoimmune Diseases
title_full Advances of Regulatory B Cells in Autoimmune Diseases
title_fullStr Advances of Regulatory B Cells in Autoimmune Diseases
title_full_unstemmed Advances of Regulatory B Cells in Autoimmune Diseases
title_short Advances of Regulatory B Cells in Autoimmune Diseases
title_sort advances of regulatory b cells in autoimmune diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082147/
https://www.ncbi.nlm.nih.gov/pubmed/33936028
http://dx.doi.org/10.3389/fimmu.2021.592914
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