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Advances of Regulatory B Cells in Autoimmune Diseases
With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive func...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082147/ https://www.ncbi.nlm.nih.gov/pubmed/33936028 http://dx.doi.org/10.3389/fimmu.2021.592914 |
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author | Zhu, Qiugang Rui, Ke Wang, Shengjun Tian, Jie |
author_facet | Zhu, Qiugang Rui, Ke Wang, Shengjun Tian, Jie |
author_sort | Zhu, Qiugang |
collection | PubMed |
description | With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive functions via diverse mechanisms, including the secretion of anti-inflammatory cytokines and direct cell contact. The balance between Bregs and effector B cells is important for the immune tolerance. In this review, we focus on recent advances in the characteristics of Bregs and their functional roles in autoimmunity. |
format | Online Article Text |
id | pubmed-8082147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80821472021-04-30 Advances of Regulatory B Cells in Autoimmune Diseases Zhu, Qiugang Rui, Ke Wang, Shengjun Tian, Jie Front Immunol Immunology With the ability to induce T cell activation and elicit humoral responses, B cells are generally considered as effectors of the immune system. However, the emergence of regulatory B cells (Bregs) has given new insight into the role of B cells in immune responses. Bregs exhibit immunosuppressive functions via diverse mechanisms, including the secretion of anti-inflammatory cytokines and direct cell contact. The balance between Bregs and effector B cells is important for the immune tolerance. In this review, we focus on recent advances in the characteristics of Bregs and their functional roles in autoimmunity. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8082147/ /pubmed/33936028 http://dx.doi.org/10.3389/fimmu.2021.592914 Text en Copyright © 2021 Zhu, Rui, Wang and Tian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhu, Qiugang Rui, Ke Wang, Shengjun Tian, Jie Advances of Regulatory B Cells in Autoimmune Diseases |
title | Advances of Regulatory B Cells in Autoimmune Diseases |
title_full | Advances of Regulatory B Cells in Autoimmune Diseases |
title_fullStr | Advances of Regulatory B Cells in Autoimmune Diseases |
title_full_unstemmed | Advances of Regulatory B Cells in Autoimmune Diseases |
title_short | Advances of Regulatory B Cells in Autoimmune Diseases |
title_sort | advances of regulatory b cells in autoimmune diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082147/ https://www.ncbi.nlm.nih.gov/pubmed/33936028 http://dx.doi.org/10.3389/fimmu.2021.592914 |
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