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Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis

Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotic...

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Autor principal: Hites, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082150/
https://www.ncbi.nlm.nih.gov/pubmed/33937283
http://dx.doi.org/10.3389/fmed.2021.640740
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author Hites, Maya
author_facet Hites, Maya
author_sort Hites, Maya
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description Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotics in a rapid fashion to obtain adequate drug concentrations at the site of the infection can improve survival of patients. Nevertheless, it is a challenge for clinicians to do so. Indeed, clinicians today are regularly confronted with infections due to very resistant pathogens, and standard dosage regimens of antibiotics often do not provide adequate antibiotic concentrations at the site of the infection. We provide a narrative minireview of different anti-infectious treatments currently available and suggestions on how to deliver optimized dosage regimens to septic patients. Particular emphasis will be made on newly available anti-infectious therapies.
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spelling pubmed-80821502021-04-30 Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis Hites, Maya Front Med (Lausanne) Medicine Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotics in a rapid fashion to obtain adequate drug concentrations at the site of the infection can improve survival of patients. Nevertheless, it is a challenge for clinicians to do so. Indeed, clinicians today are regularly confronted with infections due to very resistant pathogens, and standard dosage regimens of antibiotics often do not provide adequate antibiotic concentrations at the site of the infection. We provide a narrative minireview of different anti-infectious treatments currently available and suggestions on how to deliver optimized dosage regimens to septic patients. Particular emphasis will be made on newly available anti-infectious therapies. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8082150/ /pubmed/33937283 http://dx.doi.org/10.3389/fmed.2021.640740 Text en Copyright © 2021 Hites. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Hites, Maya
Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title_full Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title_fullStr Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title_full_unstemmed Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title_short Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis
title_sort minireview on novel anti-infectious treatment options and optimized drug regimens for sepsis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082150/
https://www.ncbi.nlm.nih.gov/pubmed/33937283
http://dx.doi.org/10.3389/fmed.2021.640740
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