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Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability

Knee osteoarthritis (KOA) is a very common condition with multifactorial etiology leading to severe pain and disability in the adult population. Although KOA is considered a non-inflammatory arthritis, upregulation of inflammatory and catabolic pathways with increased production of proinflammatory c...

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Autores principales: Santoprete, Stefano, Marchetti, Federica, Rubino, Carlotta, Bedini, Maria Grazie, Nasto, Luigi Aurelio, Cipolloni, Valerio, Pola, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082170/
https://www.ncbi.nlm.nih.gov/pubmed/33936575
http://dx.doi.org/10.4081/or.2021.9161
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author Santoprete, Stefano
Marchetti, Federica
Rubino, Carlotta
Bedini, Maria Grazie
Nasto, Luigi Aurelio
Cipolloni, Valerio
Pola, Enrico
author_facet Santoprete, Stefano
Marchetti, Federica
Rubino, Carlotta
Bedini, Maria Grazie
Nasto, Luigi Aurelio
Cipolloni, Valerio
Pola, Enrico
author_sort Santoprete, Stefano
collection PubMed
description Knee osteoarthritis (KOA) is a very common condition with multifactorial etiology leading to severe pain and disability in the adult population. Although KOA is considered a non-inflammatory arthritis, upregulation of inflammatory and catabolic pathways with increased production of proinflammatory cytokines leading to cartilage degradation and extracellular matrix degeneration has been reported. Intra-articular injection of fresh fat derived stromal vascular fraction (SVF) fraction has been proposed as a valid and alternative treatment for symptomatic KOA that guarantees mechanical support through viscosupplementation, anti-inflammatory, and anabolic action. We retrospectively reviewed a case series of 84 consecutive adult patients with KOA who underwent intra-articular injection of fresh fat derived SVF. Significant improvement in pain levels (NRS score decrease 3.5±1.1, p<0.001), WOMAC pain (-7.02±3.45 score change, p<0.001), WOMAC stiffness (-1.97±1.02, p<0.001), and ROM improvement (+17.13±5.22°, p<0.001). The only complication noted was knee joint swelling lasting for less than 7 days after the injection in 7% of the patients.
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spelling pubmed-80821702021-04-30 Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability Santoprete, Stefano Marchetti, Federica Rubino, Carlotta Bedini, Maria Grazie Nasto, Luigi Aurelio Cipolloni, Valerio Pola, Enrico Orthop Rev (Pavia) Article Knee osteoarthritis (KOA) is a very common condition with multifactorial etiology leading to severe pain and disability in the adult population. Although KOA is considered a non-inflammatory arthritis, upregulation of inflammatory and catabolic pathways with increased production of proinflammatory cytokines leading to cartilage degradation and extracellular matrix degeneration has been reported. Intra-articular injection of fresh fat derived stromal vascular fraction (SVF) fraction has been proposed as a valid and alternative treatment for symptomatic KOA that guarantees mechanical support through viscosupplementation, anti-inflammatory, and anabolic action. We retrospectively reviewed a case series of 84 consecutive adult patients with KOA who underwent intra-articular injection of fresh fat derived SVF. Significant improvement in pain levels (NRS score decrease 3.5±1.1, p<0.001), WOMAC pain (-7.02±3.45 score change, p<0.001), WOMAC stiffness (-1.97±1.02, p<0.001), and ROM improvement (+17.13±5.22°, p<0.001). The only complication noted was knee joint swelling lasting for less than 7 days after the injection in 7% of the patients. PAGEPress Publications, Pavia, Italy 2021-03-31 /pmc/articles/PMC8082170/ /pubmed/33936575 http://dx.doi.org/10.4081/or.2021.9161 Text en ©Copyright: the Author(s) https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Article
Santoprete, Stefano
Marchetti, Federica
Rubino, Carlotta
Bedini, Maria Grazie
Nasto, Luigi Aurelio
Cipolloni, Valerio
Pola, Enrico
Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title_full Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title_fullStr Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title_full_unstemmed Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title_short Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
title_sort fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082170/
https://www.ncbi.nlm.nih.gov/pubmed/33936575
http://dx.doi.org/10.4081/or.2021.9161
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