Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma

BACKGROUND: Less than 20% of melanoma patients respond to programmed cell death-1 (PD-1) blockade immunotherapies. Thus, it is crucial to understand the dynamic changes in the tumor microenvironment (TME) after PD-1 blockade, for developing immunotherapy efficacy. METHODS: A genomic analysis was con...

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Detalles Bibliográficos
Autores principales: Huang, Lili, Xu, Yu, Fang, Juemin, Liu, Weixing, Chen, Jianhua, Liu, Zhuqing, Xu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082190/
https://www.ncbi.nlm.nih.gov/pubmed/33936081
http://dx.doi.org/10.3389/fimmu.2021.654749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082190/
https://www.ncbi.nlm.nih.gov/pubmed/33936081
http://dx.doi.org/10.3389/fimmu.2021.654749

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