Cargando…

The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus

During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It...

Descripción completa

Detalles Bibliográficos
Autores principales: de Araujo, Talita Stelling, Barbosa, Glauce Moreno, Sanches, Karoline, Azevedo, Jéssica M., dos Santos Cabral, Katia Maria, Almeida, Marcius S., Almeida, Fabio C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082218/
https://www.ncbi.nlm.nih.gov/pubmed/33914244
http://dx.doi.org/10.1007/s12104-021-10027-6
_version_ 1783685807072083968
author de Araujo, Talita Stelling
Barbosa, Glauce Moreno
Sanches, Karoline
Azevedo, Jéssica M.
dos Santos Cabral, Katia Maria
Almeida, Marcius S.
Almeida, Fabio C. L.
author_facet de Araujo, Talita Stelling
Barbosa, Glauce Moreno
Sanches, Karoline
Azevedo, Jéssica M.
dos Santos Cabral, Katia Maria
Almeida, Marcius S.
Almeida, Fabio C. L.
author_sort de Araujo, Talita Stelling
collection PubMed
description During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).
format Online
Article
Text
id pubmed-8082218
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-80822182021-04-29 The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus de Araujo, Talita Stelling Barbosa, Glauce Moreno Sanches, Karoline Azevedo, Jéssica M. dos Santos Cabral, Katia Maria Almeida, Marcius S. Almeida, Fabio C. L. Biomol NMR Assign Article During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS). Springer Netherlands 2021-04-29 2021 /pmc/articles/PMC8082218/ /pubmed/33914244 http://dx.doi.org/10.1007/s12104-021-10027-6 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
de Araujo, Talita Stelling
Barbosa, Glauce Moreno
Sanches, Karoline
Azevedo, Jéssica M.
dos Santos Cabral, Katia Maria
Almeida, Marcius S.
Almeida, Fabio C. L.
The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title_full The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title_fullStr The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title_full_unstemmed The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title_short The (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus
title_sort (1)h, (15)n, and (13)c resonance assignments of the n-terminal domain of the nucleocapsid protein from the middle east respiratory syndrome coronavirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082218/
https://www.ncbi.nlm.nih.gov/pubmed/33914244
http://dx.doi.org/10.1007/s12104-021-10027-6
work_keys_str_mv AT dearaujotalitastelling the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT barbosaglaucemoreno the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT sancheskaroline the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT azevedojessicam the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT dossantoscabralkatiamaria the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT almeidamarciuss the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT almeidafabiocl the1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT dearaujotalitastelling 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT barbosaglaucemoreno 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT sancheskaroline 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT azevedojessicam 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT dossantoscabralkatiamaria 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT almeidamarciuss 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus
AT almeidafabiocl 1h15nand13cresonanceassignmentsofthenterminaldomainofthenucleocapsidproteinfromthemiddleeastrespiratorysyndromecoronavirus