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Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

BACKGROUND: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS)...

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Detalles Bibliográficos
Autores principales:	Sriramajayam, Kannappan, Peng, Dunfa, Lu, Heng, Zhou, Shoumin, Bhat, Nadeem, McDonald, Oliver G., Que, Jianwen, Zaika, Alexander, El-Rifai, Wael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082268/ https://www.ncbi.nlm.nih.gov/pubmed/33887608 http://dx.doi.org/10.1016/j.redox.2021.101970

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