RAD51: Beyond the break

As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabol...

Descripción completa

Detalles Bibliográficos
Autores principales: Wassing, Isabel E., Esashi, Fumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082279/
https://www.ncbi.nlm.nih.gov/pubmed/32938550
http://dx.doi.org/10.1016/j.semcdb.2020.08.010
_version_ 1783685820012560384
author Wassing, Isabel E.
Esashi, Fumiko
author_facet Wassing, Isabel E.
Esashi, Fumiko
author_sort Wassing, Isabel E.
collection PubMed
description As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword.
format Online
Article
Text
id pubmed-8082279
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Academic Press
record_format MEDLINE/PubMed
spelling pubmed-80822792021-05-05 RAD51: Beyond the break Wassing, Isabel E. Esashi, Fumiko Semin Cell Dev Biol Review As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword. Academic Press 2021-05 /pmc/articles/PMC8082279/ /pubmed/32938550 http://dx.doi.org/10.1016/j.semcdb.2020.08.010 Text en © 2020 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wassing, Isabel E.
Esashi, Fumiko
RAD51: Beyond the break
title RAD51: Beyond the break
title_full RAD51: Beyond the break
title_fullStr RAD51: Beyond the break
title_full_unstemmed RAD51: Beyond the break
title_short RAD51: Beyond the break
title_sort rad51: beyond the break
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082279/
https://www.ncbi.nlm.nih.gov/pubmed/32938550
http://dx.doi.org/10.1016/j.semcdb.2020.08.010
work_keys_str_mv AT wassingisabele rad51beyondthebreak
AT esashifumiko rad51beyondthebreak

Ejemplares similares