Cargando…

Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right commo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Runfang, Zhao, Tingkui, Zheng, Beibei, Zhang, Yun, Li, Xiaohui, Zhang, Feng, Cen, Juan, Duan, Shaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082391/
https://www.ncbi.nlm.nih.gov/pubmed/33935747
http://dx.doi.org/10.3389/fphar.2021.648107
_version_ 1783685834792239104
author Zhang, Runfang
Zhao, Tingkui
Zheng, Beibei
Zhang, Yun
Li, Xiaohui
Zhang, Feng
Cen, Juan
Duan, Shaofeng
author_facet Zhang, Runfang
Zhao, Tingkui
Zheng, Beibei
Zhang, Yun
Li, Xiaohui
Zhang, Feng
Cen, Juan
Duan, Shaofeng
author_sort Zhang, Runfang
collection PubMed
description In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right common carotid artery occlusion (rUCCAO) was established. After two weeks of curcumin administration, the cognitive function of mice was detected by Morris water maze and Y maze. The alteration on oxidative injuries and morphological damage were also analyzed by reactive oxygen species, superoxide dismutase, GSH, malondialdehyde tests, and Nissl stain on cortex/hippocampus. The angiogenesis and related signal factors were evaluated as well. The results showed that Cur20 significantly attenuated the cognitive dysfunction and histopathological changes of the VaD mice with enhanced antioxidant system and angiogenesis. In addition, primary rat brain microvessel endothelial cells (rBMECs) with oxygen glucose deprivation (OGD) were applied to further verify the possible mechanisms of Cur20-induced angiogenesis. The results demonstrated that the proliferation effect and the activation of pro-angiogenesis factors such as HIF-1α, VEGF, and TFEB might contribute to the protection of ischemic injury. Based on the above, our conclusion is that Cur20 can be considered as a promising therapeutic strategy for VaD.
format Online
Article
Text
id pubmed-8082391
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80823912021-04-30 Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis Zhang, Runfang Zhao, Tingkui Zheng, Beibei Zhang, Yun Li, Xiaohui Zhang, Feng Cen, Juan Duan, Shaofeng Front Pharmacol Pharmacology In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right common carotid artery occlusion (rUCCAO) was established. After two weeks of curcumin administration, the cognitive function of mice was detected by Morris water maze and Y maze. The alteration on oxidative injuries and morphological damage were also analyzed by reactive oxygen species, superoxide dismutase, GSH, malondialdehyde tests, and Nissl stain on cortex/hippocampus. The angiogenesis and related signal factors were evaluated as well. The results showed that Cur20 significantly attenuated the cognitive dysfunction and histopathological changes of the VaD mice with enhanced antioxidant system and angiogenesis. In addition, primary rat brain microvessel endothelial cells (rBMECs) with oxygen glucose deprivation (OGD) were applied to further verify the possible mechanisms of Cur20-induced angiogenesis. The results demonstrated that the proliferation effect and the activation of pro-angiogenesis factors such as HIF-1α, VEGF, and TFEB might contribute to the protection of ischemic injury. Based on the above, our conclusion is that Cur20 can be considered as a promising therapeutic strategy for VaD. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8082391/ /pubmed/33935747 http://dx.doi.org/10.3389/fphar.2021.648107 Text en Copyright © 2021 Zhang, Zhao, Zheng, Zhang, Li, Zhang, Cen and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Runfang
Zhao, Tingkui
Zheng, Beibei
Zhang, Yun
Li, Xiaohui
Zhang, Feng
Cen, Juan
Duan, Shaofeng
Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title_full Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title_fullStr Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title_full_unstemmed Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title_short Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis
title_sort curcumin derivative cur20 attenuated cerebral ischemic injury by antioxidant effect and hif-1α/vegf/tfeb-activated angiogenesis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082391/
https://www.ncbi.nlm.nih.gov/pubmed/33935747
http://dx.doi.org/10.3389/fphar.2021.648107
work_keys_str_mv AT zhangrunfang curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT zhaotingkui curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT zhengbeibei curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT zhangyun curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT lixiaohui curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT zhangfeng curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT cenjuan curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis
AT duanshaofeng curcuminderivativecur20attenuatedcerebralischemicinjurybyantioxidanteffectandhif1avegftfebactivatedangiogenesis