Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in the surgical patients admitted to the intensive...

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Detalles Bibliográficos
Autores principales: Neskovic, Nenad, Mandic, Dario, Marczi, Saska, Skiljic, Sonja, Kristek, Gordana, Vinkovic, Hrvoje, Mraovic, Boris, Debeljak, Zeljko, Kvolik, Slavica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082457/
https://www.ncbi.nlm.nih.gov/pubmed/33935773
http://dx.doi.org/10.3389/fphar.2021.656748

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