SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism

Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional...

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Autores principales: Shen, Shu, Zhang, Jingyuan, Fang, Yaohui, Lu, Sihong, Wu, Jun, Zheng, Xin, Deng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082485/
https://www.ncbi.nlm.nih.gov/pubmed/33926500
http://dx.doi.org/10.1186/s13045-021-01082-6
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author Shen, Shu
Zhang, Jingyuan
Fang, Yaohui
Lu, Sihong
Wu, Jun
Zheng, Xin
Deng, Fei
author_facet Shen, Shu
Zhang, Jingyuan
Fang, Yaohui
Lu, Sihong
Wu, Jun
Zheng, Xin
Deng, Fei
author_sort Shen, Shu
collection PubMed
description Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional receptor ACE2 and alternative receptors or co-factors for SARS-CoV-2 entry was characterized in platelets from COVID-19 patients and healthy persons as well as human megakaryocytes based on laboratory tests or previously reported RNA-seq data. The results suggest that SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism and may regulate alternative receptor expression associated with COVID-19 coagulation dysfunction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13045-021-01082-6.
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spelling pubmed-80824852021-04-29 SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism Shen, Shu Zhang, Jingyuan Fang, Yaohui Lu, Sihong Wu, Jun Zheng, Xin Deng, Fei J Hematol Oncol Letter to the Editor Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional receptor ACE2 and alternative receptors or co-factors for SARS-CoV-2 entry was characterized in platelets from COVID-19 patients and healthy persons as well as human megakaryocytes based on laboratory tests or previously reported RNA-seq data. The results suggest that SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism and may regulate alternative receptor expression associated with COVID-19 coagulation dysfunction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13045-021-01082-6. BioMed Central 2021-04-29 /pmc/articles/PMC8082485/ /pubmed/33926500 http://dx.doi.org/10.1186/s13045-021-01082-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Shen, Shu
Zhang, Jingyuan
Fang, Yaohui
Lu, Sihong
Wu, Jun
Zheng, Xin
Deng, Fei
SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title_full SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title_fullStr SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title_full_unstemmed SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title_short SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
title_sort sars-cov-2 interacts with platelets and megakaryocytes via ace2-independent mechanism
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082485/
https://www.ncbi.nlm.nih.gov/pubmed/33926500
http://dx.doi.org/10.1186/s13045-021-01082-6
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