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Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. Due to developmental changes in pharmacokinetics and pharmacodynamics, physiologically based pharmacokinetic (PBPK) models are built to better predict drug exposure in children and to a...

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Detalles Bibliográficos
Autores principales:	Buyssens, Laura, De Clerck, Laura, Schelstraete, Wim, Dhaenens, Maarten, Deforce, Dieter, Ayuso, Miriam, Van Ginneken, Chris, Van Cruchten, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082684/ https://www.ncbi.nlm.nih.gov/pubmed/33935788 http://dx.doi.org/10.3389/fphar.2021.665644

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