The emerging role of β-secretases in cancer

BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as they are responsible for the processing of APP in neurotoxic Aβ peptides. These proteas...

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Detalles Bibliográficos
Autores principales: Farris, Francesco, Matafora, Vittoria, Bachi, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082908/
https://www.ncbi.nlm.nih.gov/pubmed/33926496
http://dx.doi.org/10.1186/s13046-021-01953-3
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author Farris, Francesco
Matafora, Vittoria
Bachi, Angela
author_facet Farris, Francesco
Matafora, Vittoria
Bachi, Angela
author_sort Farris, Francesco
collection PubMed
description BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as they are responsible for the processing of APP in neurotoxic Aβ peptides. These proteases, especially BACE2, are overexpressed in tumors and correlate with poor prognosis. Recently, different research groups tried to address the role of BACE1 and 2 in cancer development and progression. In this review, we summarize the latest findings on β-secretases in cancer, highlighting the mechanisms that build the rationale to propose inhibitors of these proteins as a new line of treatment for different tumor types.
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spelling pubmed-80829082021-04-29 The emerging role of β-secretases in cancer Farris, Francesco Matafora, Vittoria Bachi, Angela J Exp Clin Cancer Res Review BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as they are responsible for the processing of APP in neurotoxic Aβ peptides. These proteases, especially BACE2, are overexpressed in tumors and correlate with poor prognosis. Recently, different research groups tried to address the role of BACE1 and 2 in cancer development and progression. In this review, we summarize the latest findings on β-secretases in cancer, highlighting the mechanisms that build the rationale to propose inhibitors of these proteins as a new line of treatment for different tumor types. BioMed Central 2021-04-29 /pmc/articles/PMC8082908/ /pubmed/33926496 http://dx.doi.org/10.1186/s13046-021-01953-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Farris, Francesco
Matafora, Vittoria
Bachi, Angela
The emerging role of β-secretases in cancer
title The emerging role of β-secretases in cancer
title_full The emerging role of β-secretases in cancer
title_fullStr The emerging role of β-secretases in cancer
title_full_unstemmed The emerging role of β-secretases in cancer
title_short The emerging role of β-secretases in cancer
title_sort emerging role of β-secretases in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082908/
https://www.ncbi.nlm.nih.gov/pubmed/33926496
http://dx.doi.org/10.1186/s13046-021-01953-3
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