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Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study
BACKGROUND: The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-contr...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082925/ https://www.ncbi.nlm.nih.gov/pubmed/33910586 http://dx.doi.org/10.1186/s12940-021-00729-8 |
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author | Meloni, Federico Satta, Giannina Padoan, Marina Montagna, Andrea Pilia, Ilaria Argiolas, Alessandra Piro, Sara Magnani, Corrado Gambelunghe, Angela Muzi, Giacomo Ferri, Giovanni Maria Vimercati, Luigi Zanotti, Roberta Scarpa, Aldo Zucca, Mariagrazia De Matteis, Sara Campagna, Marcello Miligi, Lucia Cocco, Pierluigi |
author_facet | Meloni, Federico Satta, Giannina Padoan, Marina Montagna, Andrea Pilia, Ilaria Argiolas, Alessandra Piro, Sara Magnani, Corrado Gambelunghe, Angela Muzi, Giacomo Ferri, Giovanni Maria Vimercati, Luigi Zanotti, Roberta Scarpa, Aldo Zucca, Mariagrazia De Matteis, Sara Campagna, Marcello Miligi, Lucia Cocco, Pierluigi |
author_sort | Meloni, Federico |
collection | PubMed |
description | BACKGROUND: The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy. METHODS: The Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011–17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre. RESULTS: Very few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 × 10(− 4). There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL. CONCLUSIONS: Our findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen. |
format | Online Article Text |
id | pubmed-8082925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80829252021-04-29 Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study Meloni, Federico Satta, Giannina Padoan, Marina Montagna, Andrea Pilia, Ilaria Argiolas, Alessandra Piro, Sara Magnani, Corrado Gambelunghe, Angela Muzi, Giacomo Ferri, Giovanni Maria Vimercati, Luigi Zanotti, Roberta Scarpa, Aldo Zucca, Mariagrazia De Matteis, Sara Campagna, Marcello Miligi, Lucia Cocco, Pierluigi Environ Health Research BACKGROUND: The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy. METHODS: The Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011–17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre. RESULTS: Very few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 × 10(− 4). There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL. CONCLUSIONS: Our findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen. BioMed Central 2021-04-28 /pmc/articles/PMC8082925/ /pubmed/33910586 http://dx.doi.org/10.1186/s12940-021-00729-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Meloni, Federico Satta, Giannina Padoan, Marina Montagna, Andrea Pilia, Ilaria Argiolas, Alessandra Piro, Sara Magnani, Corrado Gambelunghe, Angela Muzi, Giacomo Ferri, Giovanni Maria Vimercati, Luigi Zanotti, Roberta Scarpa, Aldo Zucca, Mariagrazia De Matteis, Sara Campagna, Marcello Miligi, Lucia Cocco, Pierluigi Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title | Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title_full | Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title_fullStr | Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title_full_unstemmed | Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title_short | Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study |
title_sort | occupational exposure to glyphosate and risk of lymphoma:results of an italian multicenter case-control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082925/ https://www.ncbi.nlm.nih.gov/pubmed/33910586 http://dx.doi.org/10.1186/s12940-021-00729-8 |
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