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Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective

The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus...

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Autores principales: Sethi, Sidharth Kumar, Rana, Abhyuday, Adnani, Harsha, McCulloch, Mignon, Alhasan, Khalid, Sultana, Azmeri, Safadi, Rama, Agrawal, Nirav, Raina, Rupesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083308/
https://www.ncbi.nlm.nih.gov/pubmed/34471522
http://dx.doi.org/10.1093/ckj/sfab073
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author Sethi, Sidharth Kumar
Rana, Abhyuday
Adnani, Harsha
McCulloch, Mignon
Alhasan, Khalid
Sultana, Azmeri
Safadi, Rama
Agrawal, Nirav
Raina, Rupesh
author_facet Sethi, Sidharth Kumar
Rana, Abhyuday
Adnani, Harsha
McCulloch, Mignon
Alhasan, Khalid
Sultana, Azmeri
Safadi, Rama
Agrawal, Nirav
Raina, Rupesh
author_sort Sethi, Sidharth Kumar
collection PubMed
description The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus 2 infection in children with MIS-C is more common than initially thought and is associated with higher morbidity and mortality. There are several reports of a direct viral tropism of coronavirus disease 2019 and MIS-C-associated renal damage. This study’s objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients. Furthermore, we discuss the multifactorial pathogenesis contributing to acute kidney injury (AKI) development in MIS-C. The current review gives a pediatric nephrologist’s perspective of the renal involvement in MIS-C, the incidence of AKI, the pathophysiology of AKI in MIS-C and the proposed therapeutic regimens available, including the need for kidney replacement therapy for a child with AKI associated with MIS-C. As the disease is rapidly evolving, more detailed clinical prospective studies are required to understand MIS-C and its role in AKI better.
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spelling pubmed-80833082021-05-03 Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective Sethi, Sidharth Kumar Rana, Abhyuday Adnani, Harsha McCulloch, Mignon Alhasan, Khalid Sultana, Azmeri Safadi, Rama Agrawal, Nirav Raina, Rupesh Clin Kidney J Ckj Reviews The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus 2 infection in children with MIS-C is more common than initially thought and is associated with higher morbidity and mortality. There are several reports of a direct viral tropism of coronavirus disease 2019 and MIS-C-associated renal damage. This study’s objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients. Furthermore, we discuss the multifactorial pathogenesis contributing to acute kidney injury (AKI) development in MIS-C. The current review gives a pediatric nephrologist’s perspective of the renal involvement in MIS-C, the incidence of AKI, the pathophysiology of AKI in MIS-C and the proposed therapeutic regimens available, including the need for kidney replacement therapy for a child with AKI associated with MIS-C. As the disease is rapidly evolving, more detailed clinical prospective studies are required to understand MIS-C and its role in AKI better. Oxford University Press 2021-04-15 /pmc/articles/PMC8083308/ /pubmed/34471522 http://dx.doi.org/10.1093/ckj/sfab073 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Ckj Reviews
Sethi, Sidharth Kumar
Rana, Abhyuday
Adnani, Harsha
McCulloch, Mignon
Alhasan, Khalid
Sultana, Azmeri
Safadi, Rama
Agrawal, Nirav
Raina, Rupesh
Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title_full Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title_fullStr Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title_full_unstemmed Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title_short Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
title_sort kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
topic Ckj Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083308/
https://www.ncbi.nlm.nih.gov/pubmed/34471522
http://dx.doi.org/10.1093/ckj/sfab073
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