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Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective
The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083308/ https://www.ncbi.nlm.nih.gov/pubmed/34471522 http://dx.doi.org/10.1093/ckj/sfab073 |
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author | Sethi, Sidharth Kumar Rana, Abhyuday Adnani, Harsha McCulloch, Mignon Alhasan, Khalid Sultana, Azmeri Safadi, Rama Agrawal, Nirav Raina, Rupesh |
author_facet | Sethi, Sidharth Kumar Rana, Abhyuday Adnani, Harsha McCulloch, Mignon Alhasan, Khalid Sultana, Azmeri Safadi, Rama Agrawal, Nirav Raina, Rupesh |
author_sort | Sethi, Sidharth Kumar |
collection | PubMed |
description | The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus 2 infection in children with MIS-C is more common than initially thought and is associated with higher morbidity and mortality. There are several reports of a direct viral tropism of coronavirus disease 2019 and MIS-C-associated renal damage. This study’s objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients. Furthermore, we discuss the multifactorial pathogenesis contributing to acute kidney injury (AKI) development in MIS-C. The current review gives a pediatric nephrologist’s perspective of the renal involvement in MIS-C, the incidence of AKI, the pathophysiology of AKI in MIS-C and the proposed therapeutic regimens available, including the need for kidney replacement therapy for a child with AKI associated with MIS-C. As the disease is rapidly evolving, more detailed clinical prospective studies are required to understand MIS-C and its role in AKI better. |
format | Online Article Text |
id | pubmed-8083308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80833082021-05-03 Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective Sethi, Sidharth Kumar Rana, Abhyuday Adnani, Harsha McCulloch, Mignon Alhasan, Khalid Sultana, Azmeri Safadi, Rama Agrawal, Nirav Raina, Rupesh Clin Kidney J Ckj Reviews The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus 2 infection in children with MIS-C is more common than initially thought and is associated with higher morbidity and mortality. There are several reports of a direct viral tropism of coronavirus disease 2019 and MIS-C-associated renal damage. This study’s objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients. Furthermore, we discuss the multifactorial pathogenesis contributing to acute kidney injury (AKI) development in MIS-C. The current review gives a pediatric nephrologist’s perspective of the renal involvement in MIS-C, the incidence of AKI, the pathophysiology of AKI in MIS-C and the proposed therapeutic regimens available, including the need for kidney replacement therapy for a child with AKI associated with MIS-C. As the disease is rapidly evolving, more detailed clinical prospective studies are required to understand MIS-C and its role in AKI better. Oxford University Press 2021-04-15 /pmc/articles/PMC8083308/ /pubmed/34471522 http://dx.doi.org/10.1093/ckj/sfab073 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Ckj Reviews Sethi, Sidharth Kumar Rana, Abhyuday Adnani, Harsha McCulloch, Mignon Alhasan, Khalid Sultana, Azmeri Safadi, Rama Agrawal, Nirav Raina, Rupesh Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title | Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title_full | Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title_fullStr | Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title_full_unstemmed | Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title_short | Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
title_sort | kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist’s perspective |
topic | Ckj Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083308/ https://www.ncbi.nlm.nih.gov/pubmed/34471522 http://dx.doi.org/10.1093/ckj/sfab073 |
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