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Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit

BACKGROUND: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer. AIMS & OBJECTIVES: In this study, an attempt has been made to assess...

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Autores principales: Santoshi, Chatraspalli Krishna, Kumar, Jogishetty Vijay, Bhagirath, Pacha Venkat, Vinay, B Hari, Prakash, Y John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083430/
https://www.ncbi.nlm.nih.gov/pubmed/33967506
http://dx.doi.org/10.4103/jomfp.JOMFP_55_20
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author Santoshi, Chatraspalli Krishna
Kumar, Jogishetty Vijay
Bhagirath, Pacha Venkat
Vinay, B Hari
Prakash, Y John
author_facet Santoshi, Chatraspalli Krishna
Kumar, Jogishetty Vijay
Bhagirath, Pacha Venkat
Vinay, B Hari
Prakash, Y John
author_sort Santoshi, Chatraspalli Krishna
collection PubMed
description BACKGROUND: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer. AIMS & OBJECTIVES: In this study, an attempt has been made to assess the morphological alterations of the nuclei of the basal cells in OPMDs and oral squamous cell carcinoma (OSCC). Our objective was to compare the alterations and to assess the predictive factor of such alterations of basal cells in malignant transformation of OPMDs to OSCC. MATERIALS AND METHODS: This was a retrospective study conducted on tissue sections of 150 formalin fixed, paraffin embedded blocks obtained from the archives. The specimens were grouped into OSCC group (n= 50) and OPMDs (n= 100). Nuclear features were evaluated using computer- assisted microscopic image analysis. One- way ANOVA analysis was done to verify the difference between the groups for all variables. RESULTS: Our results showed statistically significant difference for all parameters between the groups. Among OPMDs, leukoplakia showed significant increase in nuclear area, nuclear perimeter, Nuclear/Cytoplasm (N/C) ratio, density and loss of polarity, while OSF showed significance with only perimeter, density and loss of polarity. CONCLUSION: Based on findings of present study, it is concluded that measurements using computer- aided morphometric analysis may provide an objective means for predicting the malignant transformation OPMDs to OSCC. Among OPMDs, Leukoplakia has a higher chance of malignant transformation than OSF
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spelling pubmed-80834302021-05-06 Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit Santoshi, Chatraspalli Krishna Kumar, Jogishetty Vijay Bhagirath, Pacha Venkat Vinay, B Hari Prakash, Y John J Oral Maxillofac Pathol Original Article BACKGROUND: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer. AIMS & OBJECTIVES: In this study, an attempt has been made to assess the morphological alterations of the nuclei of the basal cells in OPMDs and oral squamous cell carcinoma (OSCC). Our objective was to compare the alterations and to assess the predictive factor of such alterations of basal cells in malignant transformation of OPMDs to OSCC. MATERIALS AND METHODS: This was a retrospective study conducted on tissue sections of 150 formalin fixed, paraffin embedded blocks obtained from the archives. The specimens were grouped into OSCC group (n= 50) and OPMDs (n= 100). Nuclear features were evaluated using computer- assisted microscopic image analysis. One- way ANOVA analysis was done to verify the difference between the groups for all variables. RESULTS: Our results showed statistically significant difference for all parameters between the groups. Among OPMDs, leukoplakia showed significant increase in nuclear area, nuclear perimeter, Nuclear/Cytoplasm (N/C) ratio, density and loss of polarity, while OSF showed significance with only perimeter, density and loss of polarity. CONCLUSION: Based on findings of present study, it is concluded that measurements using computer- aided morphometric analysis may provide an objective means for predicting the malignant transformation OPMDs to OSCC. Among OPMDs, Leukoplakia has a higher chance of malignant transformation than OSF Wolters Kluwer - Medknow 2020 2021-01-09 /pmc/articles/PMC8083430/ /pubmed/33967506 http://dx.doi.org/10.4103/jomfp.JOMFP_55_20 Text en Copyright: © 2021 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Santoshi, Chatraspalli Krishna
Kumar, Jogishetty Vijay
Bhagirath, Pacha Venkat
Vinay, B Hari
Prakash, Y John
Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title_full Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title_fullStr Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title_full_unstemmed Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title_short Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
title_sort morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083430/
https://www.ncbi.nlm.nih.gov/pubmed/33967506
http://dx.doi.org/10.4103/jomfp.JOMFP_55_20
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