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Castleman's disease
Castleman's disease, a type of lymph node hyperplasia, usually occurs in the mediastinum and rarely presents in the cervical region as an asymptomatic solitary mass. Clinically, they are of two types-solitary and multi-centric. Most of the solitary types are asymptomatic with no associated symp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083446/ https://www.ncbi.nlm.nih.gov/pubmed/33967527 http://dx.doi.org/10.4103/jomfp.JOMFP_283_20 |
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author | Srivastava, Himanshu Reddy, Dulganti Santosh Shah, Shreyas N Shah, Vandana |
author_facet | Srivastava, Himanshu Reddy, Dulganti Santosh Shah, Shreyas N Shah, Vandana |
author_sort | Srivastava, Himanshu |
collection | PubMed |
description | Castleman's disease, a type of lymph node hyperplasia, usually occurs in the mediastinum and rarely presents in the cervical region as an asymptomatic solitary mass. Clinically, they are of two types-solitary and multi-centric. Most of the solitary types are asymptomatic with no associated symptoms, whereas the multi-centric type is associated with systemic symptoms and has a poor prognosis. Histologically, they can be classified as–Hyaline vascular, plasma cell, transitional and stromal rich type. We report a case of Castleman's disease involving the submandibular lymph node in a 75-year-old male patient whose definitive diagnosis was made only on histological examination. Isolated Castleman's disease of the submandibular node is rare and a thorough clinical and histological examination is necessary to rule out the systemic form of the disease and other diseases with manifestations as a cervical lymph node enlargement. |
format | Online Article Text |
id | pubmed-8083446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80834462021-05-06 Castleman's disease Srivastava, Himanshu Reddy, Dulganti Santosh Shah, Shreyas N Shah, Vandana J Oral Maxillofac Pathol Case Report Castleman's disease, a type of lymph node hyperplasia, usually occurs in the mediastinum and rarely presents in the cervical region as an asymptomatic solitary mass. Clinically, they are of two types-solitary and multi-centric. Most of the solitary types are asymptomatic with no associated symptoms, whereas the multi-centric type is associated with systemic symptoms and has a poor prognosis. Histologically, they can be classified as–Hyaline vascular, plasma cell, transitional and stromal rich type. We report a case of Castleman's disease involving the submandibular lymph node in a 75-year-old male patient whose definitive diagnosis was made only on histological examination. Isolated Castleman's disease of the submandibular node is rare and a thorough clinical and histological examination is necessary to rule out the systemic form of the disease and other diseases with manifestations as a cervical lymph node enlargement. Wolters Kluwer - Medknow 2020 2021-01-09 /pmc/articles/PMC8083446/ /pubmed/33967527 http://dx.doi.org/10.4103/jomfp.JOMFP_283_20 Text en Copyright: © 2021 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Srivastava, Himanshu Reddy, Dulganti Santosh Shah, Shreyas N Shah, Vandana Castleman's disease |
title | Castleman's disease |
title_full | Castleman's disease |
title_fullStr | Castleman's disease |
title_full_unstemmed | Castleman's disease |
title_short | Castleman's disease |
title_sort | castleman's disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083446/ https://www.ncbi.nlm.nih.gov/pubmed/33967527 http://dx.doi.org/10.4103/jomfp.JOMFP_283_20 |
work_keys_str_mv | AT srivastavahimanshu castlemansdisease AT reddydulgantisantosh castlemansdisease AT shahshreyasn castlemansdisease AT shahvandana castlemansdisease |