CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants

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This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found...

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Autores principales: Redd, Andrew D, Nardin, Alessandra, Kared, Hassen, Bloch, Evan M, Pekosz, Andrew, Laeyendecker, Oliver, Abel, Brian, Fehlings, Michael, Quinn, Thomas C, Tobian, Aaron A R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083629/
https://www.ncbi.nlm.nih.gov/pubmed/34322559
http://dx.doi.org/10.1093/ofid/ofab143
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author Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron A R
author_facet Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron A R
author_sort Redd, Andrew D
collection PubMed
description This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.
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spelling pubmed-80836292021-05-03 CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants Redd, Andrew D Nardin, Alessandra Kared, Hassen Bloch, Evan M Pekosz, Andrew Laeyendecker, Oliver Abel, Brian Fehlings, Michael Quinn, Thomas C Tobian, Aaron A R Open Forum Infect Dis Brief Report This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants. Oxford University Press 2021-03-30 /pmc/articles/PMC8083629/ /pubmed/34322559 http://dx.doi.org/10.1093/ofid/ofab143 Text en Published by Oxford University Press on behalf of Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Report
Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron A R
CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title_full CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title_fullStr CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title_full_unstemmed CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title_short CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
title_sort cd8+ t-cell responses in covid-19 convalescent individuals target conserved epitopes from multiple prominent sars-cov-2 circulating variants
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083629/
https://www.ncbi.nlm.nih.gov/pubmed/34322559
http://dx.doi.org/10.1093/ofid/ofab143
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