Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms

Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike pr...

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Detalles Bibliográficos
Autores principales: Cunningham, Janet L, Virhammar, Johan, Rönnberg, Bengt, Dopico, Xaquin Castro, Kolstad, Linda, Albinsson, Bo, Kumlien, Eva, Nääs, Anja, Klang, Andrea, Westman, Gabriel, Zetterberg, Henrik, Frithiof, Robert, Lundkvist, Åke, Karlsson Hedestam, Gunilla B, Rostami, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083780/
https://www.ncbi.nlm.nih.gov/pubmed/33744954
http://dx.doi.org/10.1093/infdis/jiab153
Descripción
Sumario:Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.

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