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Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike pr...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083780/ https://www.ncbi.nlm.nih.gov/pubmed/33744954 http://dx.doi.org/10.1093/infdis/jiab153 |
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| author | Cunningham, Janet L Virhammar, Johan Rönnberg, Bengt Dopico, Xaquin Castro Kolstad, Linda Albinsson, Bo Kumlien, Eva Nääs, Anja Klang, Andrea Westman, Gabriel Zetterberg, Henrik Frithiof, Robert Lundkvist, Åke Karlsson Hedestam, Gunilla B Rostami, Elham |
| author_facet | Cunningham, Janet L Virhammar, Johan Rönnberg, Bengt Dopico, Xaquin Castro Kolstad, Linda Albinsson, Bo Kumlien, Eva Nääs, Anja Klang, Andrea Westman, Gabriel Zetterberg, Henrik Frithiof, Robert Lundkvist, Åke Karlsson Hedestam, Gunilla B Rostami, Elham |
| author_sort | Cunningham, Janet L |
| collection | PubMed |
| description | Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables. |
| format | Online Article Text |
| id | pubmed-8083780 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80837802021-05-03 Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms Cunningham, Janet L Virhammar, Johan Rönnberg, Bengt Dopico, Xaquin Castro Kolstad, Linda Albinsson, Bo Kumlien, Eva Nääs, Anja Klang, Andrea Westman, Gabriel Zetterberg, Henrik Frithiof, Robert Lundkvist, Åke Karlsson Hedestam, Gunilla B Rostami, Elham J Infect Dis Major Articles and Brief Reports Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables. Oxford University Press 2021-03-21 /pmc/articles/PMC8083780/ /pubmed/33744954 http://dx.doi.org/10.1093/infdis/jiab153 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Major Articles and Brief Reports Cunningham, Janet L Virhammar, Johan Rönnberg, Bengt Dopico, Xaquin Castro Kolstad, Linda Albinsson, Bo Kumlien, Eva Nääs, Anja Klang, Andrea Westman, Gabriel Zetterberg, Henrik Frithiof, Robert Lundkvist, Åke Karlsson Hedestam, Gunilla B Rostami, Elham Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title | Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title_full | Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title_fullStr | Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title_full_unstemmed | Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title_short | Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms |
| title_sort | antibody responses to severe acute respiratory syndrome coronavirus 2 in the serum and cerebrospinal fluid of patients with coronavirus disease 2019 and neurological symptoms |
| topic | Major Articles and Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083780/ https://www.ncbi.nlm.nih.gov/pubmed/33744954 http://dx.doi.org/10.1093/infdis/jiab153 |
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