Protective effects of aloe vera gel (aloe baberdensis Miller) on aluminum chloride-induced reproductive toxicity in male Wistar rats

OBJECTIVE: This study aims at investigating the protective effects of aloe vera gel on aluminum chloride-induced testicular toxicity of adult Wistar rats. METHODS: Twenty male Wistar rats were randomly divided into four groups (A, B, C, and D) with five animals per group. Group A serves as the control group and received distilled water (1ml/Kg). Group B received distilled water (1ml/Kg) with 100mg/kg b.wt of aluminum chloride daily. Group C received 100mg/kg b.wt of aluminum chloride with 600mg/kg b.wt of Aloe vera gel daily. Group D received 100mg/kg b.wt of aluminum chloride with 5mg/kg b.wt of vitamin C daily. The animals were fed on standard laboratory animal diet and water ad libitum. Administration was via oral cannula for four weeks. The rats were slaughtered using cervical dislocation. The testes were harvested for seminal, biochemical and histological analysis. RESULTS: The results demonstrate that the administration of aloe vera gel (AVG) is capable of preventing testicular toxicity due to aluminum chloride. Aluminum chloride caused a significant change in the testes and seminal parameters of group B when compared to the control animals. The level of Nitric oxide (NO) increased and the level of Superoxide dismutase (SOD) decreased significantly in rats treated with aluminum chloride. CONCLUSIONS: The administration of aloe vera gel showed a preventive response in aluminum-induced testicular toxicity of rats as evidenced by histological and biochemical analysis.