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Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit

BACKGROUND AND OBJECTIVES: COVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric CO...

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Autores principales: Raina, Rupesh, Chakraborty, Ronith, Mawby, Isabelle, Agarwal, Nirav, Sethi, Sidharth, Forbes, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083920/
https://www.ncbi.nlm.nih.gov/pubmed/33928439
http://dx.doi.org/10.1007/s00467-021-05084-x
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author Raina, Rupesh
Chakraborty, Ronith
Mawby, Isabelle
Agarwal, Nirav
Sethi, Sidharth
Forbes, Michael
author_facet Raina, Rupesh
Chakraborty, Ronith
Mawby, Isabelle
Agarwal, Nirav
Sethi, Sidharth
Forbes, Michael
author_sort Raina, Rupesh
collection PubMed
description BACKGROUND AND OBJECTIVES: COVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric COVID-19 patients admitted to the ICU. AKI is a severe complication of COVID-19 among children and adolescents. METHODS: A comprehensive literature search was conducted in PubMed/MEDLINE and Cochrane Center Trials to find all published literature related to AKI in COVID-19 patients, including incidence and outcomes. RESULTS: Twenty-four studies reporting the outcomes of interest were included. Across all studies, the overall sample size of COVID positive children was 1,247 and the median age of this population was 9.1 years old. Among COVID positive pediatric patients, there was an AKI incidence of 30.51%, with only 0.56% of these patients receiving KRT. The mortality was 2.55% among all COVID positive pediatric patients. The incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID positive patients was 74.29%. CONCLUSION: AKI has shown to be a negative prognostic factor in adult patients with COVID-19 and now also in the pediatric cohort with high incidence and mortality rates. Additionally, our findings show a strong comparison in epidemiology between adult and pediatric COVID-19 patients; however, they need to be confirmed with additional data and studies. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-021-05084-x.
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spelling pubmed-80839202021-04-30 Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit Raina, Rupesh Chakraborty, Ronith Mawby, Isabelle Agarwal, Nirav Sethi, Sidharth Forbes, Michael Pediatr Nephrol Systematic Review/Meta-analysis BACKGROUND AND OBJECTIVES: COVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric COVID-19 patients admitted to the ICU. AKI is a severe complication of COVID-19 among children and adolescents. METHODS: A comprehensive literature search was conducted in PubMed/MEDLINE and Cochrane Center Trials to find all published literature related to AKI in COVID-19 patients, including incidence and outcomes. RESULTS: Twenty-four studies reporting the outcomes of interest were included. Across all studies, the overall sample size of COVID positive children was 1,247 and the median age of this population was 9.1 years old. Among COVID positive pediatric patients, there was an AKI incidence of 30.51%, with only 0.56% of these patients receiving KRT. The mortality was 2.55% among all COVID positive pediatric patients. The incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID positive patients was 74.29%. CONCLUSION: AKI has shown to be a negative prognostic factor in adult patients with COVID-19 and now also in the pediatric cohort with high incidence and mortality rates. Additionally, our findings show a strong comparison in epidemiology between adult and pediatric COVID-19 patients; however, they need to be confirmed with additional data and studies. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-021-05084-x. Springer Berlin Heidelberg 2021-04-29 2021 /pmc/articles/PMC8083920/ /pubmed/33928439 http://dx.doi.org/10.1007/s00467-021-05084-x Text en © IPNA 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Systematic Review/Meta-analysis
Raina, Rupesh
Chakraborty, Ronith
Mawby, Isabelle
Agarwal, Nirav
Sethi, Sidharth
Forbes, Michael
Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title_full Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title_fullStr Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title_full_unstemmed Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title_short Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit
title_sort critical analysis of acute kidney injury in pediatric covid-19 patients in the intensive care unit
topic Systematic Review/Meta-analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083920/
https://www.ncbi.nlm.nih.gov/pubmed/33928439
http://dx.doi.org/10.1007/s00467-021-05084-x
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