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The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration
During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083961/ https://www.ncbi.nlm.nih.gov/pubmed/33937268 http://dx.doi.org/10.3389/fcell.2021.664527 |
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author | Bo, Bing Li, Shuangshuang Zhou, Ke Wei, Jianshe |
author_facet | Bo, Bing Li, Shuangshuang Zhou, Ke Wei, Jianshe |
author_sort | Bo, Bing |
collection | PubMed |
description | During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population. |
format | Online Article Text |
id | pubmed-8083961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80839612021-04-30 The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration Bo, Bing Li, Shuangshuang Zhou, Ke Wei, Jianshe Front Cell Dev Biol Cell and Developmental Biology During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8083961/ /pubmed/33937268 http://dx.doi.org/10.3389/fcell.2021.664527 Text en Copyright © 2021 Bo, Li, Zhou and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Bo, Bing Li, Shuangshuang Zhou, Ke Wei, Jianshe The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title_full | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title_fullStr | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title_full_unstemmed | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title_short | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
title_sort | regulatory role of oxygen metabolism in exercise-induced cardiomyocyte regeneration |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083961/ https://www.ncbi.nlm.nih.gov/pubmed/33937268 http://dx.doi.org/10.3389/fcell.2021.664527 |
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