Cargando…

Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins

Voltage-gated sodium channels (NaV) have a modular architecture and contain five membrane domains. The central pore domain is responsible for ion conduction and contains a selectivity filter, while the four peripheral voltage-sensing domains (VSD-I/IV) are responsible for activation and rapid inacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Myshkin, M. Yu., Paramonov, A. S., Kulbatskii, D. S., Surkova, E. A., Berkut, A. A., Vassilevski, A. A., Lyukmanova, E. N., Kirpichnikov, M. P., Shenkarev, Z. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	A.I. Gordeyev 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084291/ https://www.ncbi.nlm.nih.gov/pubmed/33959393 http://dx.doi.org/10.32607/actanaturae.11279

Ejemplares similares

Spider toxin inhibits gating pore currents underlying periodic paralysis
por: Männikkö, Roope, et al.
Publicado: (2018)

Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Na(v)1.4 Channel
por: Myshkin, Mikhail Yu., et al.
Publicado: (2019)

Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2
por: Paramonov, Alexander S., et al.
Publicado: (2022)

Na(+)/Ca(2+) selectivity in the bacterial voltage-gated sodium channel NavAb
por: Corry, Ben
Publicado: (2013)

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors
por: Paramonov, Alexander S., et al.
Publicado: (2020)

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels
por: Lau, Carus H. Y., et al.
Publicado: (2016)

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
por: Shenkarev, Zakhar O., et al.
Publicado: (2022)

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Molecular mechanism of the spider toxin κ-LhTx-I acting on the bacterial voltage-gated sodium channel NaChBac
por: Xiao, Zhen, et al.
Publicado: (2022)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
por: Dvorak, Nolan M., et al.
Publicado: (2020)

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity
por: Kerth, Clara M., et al.
Publicado: (2020)

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer
por: Bychkov, Maxim L., et al.
Publicado: (2021)

General mechanism of spider toxin family I acting on sodium channel Nav1.7
por: Yuan, Fu-Chu, et al.
Publicado: (2022)

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors
por: Lyukmanova, E. N., et al.
Publicado: (2016)

Voltage sensor dynamics of a bacterial voltage-gated sodium channel NavAb reveal three conformational states
por: Han, Shuo, et al.
Publicado: (2023)

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer
por: Luo, Qianxuan, et al.
Publicado: (2020)

Role of the voltage-gated sodium channel Nav1.6 in glioma and candidate drugs screening
por: Ai, Yong, et al.
Publicado: (2023)

Human SLURP-1 and SLURP-2 Proteins Acting on Nicotinic Acetylcholine Receptors Reduce Proliferation of Human Colorectal Adenocarcinoma HT-29 Cells
por: Lyukmanova, E. N., et al.
Publicado: (2014)

Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study
por: Männikkö, Roope, et al.
Publicado: (2018)

Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides
por: Neff, Robert A., et al.
Publicado: (2021)

Lipid–Protein Nanodiscs Offer New Perspectives for Structural and Functional Studies of Water-Soluble Membrane-Active Peptides
por: Shenkarev, Z. O., et al.
Publicado: (2014)

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage‐gated sodium channel NavMs
por: Ireland, Sam M., et al.
Publicado: (2017)

Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor
por: Lyukmanova, E.N., et al.
Publicado: (2009)

Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
por: Bychkov, Maxim, et al.
Publicado: (2019)

Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid
por: Dongol, Yashad, et al.
Publicado: (2021)

Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes
por: Dongol, Yashad, et al.
Publicado: (2023)

Novel SCN1A mutation in the IFMT motif of the α1 subunit of the voltage-gated NaV1.1 channel causing familial hemiplegic migraine
por: De Vries, B, et al.
Publicado: (2013)

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9
por: Gilchrist, John, et al.
Publicado: (2012)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

A mechanistic reinterpretation of fast inactivation in voltage-gated Na(+) channels
por: Liu, Yichen, et al.
Publicado: (2023)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain
por: Barbosa Neto, José Osvaldo, et al.
Publicado: (2019)

Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
por: Rhana, P., et al.
Publicado: (2017)

Sporadic Erythromelalgia Associated with a Homozygous Carrier of Common Missense Polymorphism in SCN9A Gene Coding for NaV1.7 Voltage-gated Sodium Channel
por: Janicki, Piotr K, et al.
Publicado: (2019)

Shellfish Toxins Targeting Voltage-Gated Sodium Channels
por: Zhang, Fan, et al.
Publicado: (2013)

Cnidarian Toxins Acting on Voltage-Gated Ion Channels
por: Messerli, Shanta M., et al.
Publicado: (2006)

Marine Toxins That Target Voltage-gated Sodium Channels
por: Al-Sabi, Ahmed, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_5su0qh8gkt9jaoc3vtsobth6cc