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Diversity and Functions of Type II Topoisomerases
The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect – supercoiling of the molecule. Topoisomerases comprise a specific...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
A.I. Gordeyev
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084294/ https://www.ncbi.nlm.nih.gov/pubmed/33959387 http://dx.doi.org/10.32607/actanaturae.11058 |
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author | Sutormin, D. A. Galivondzhyan, A. K. Polkhovskiy, A. V. Kamalyan, S. O. Severinov, K. V. Dubiley, S. A. |
author_facet | Sutormin, D. A. Galivondzhyan, A. K. Polkhovskiy, A. V. Kamalyan, S. O. Severinov, K. V. Dubiley, S. A. |
author_sort | Sutormin, D. A. |
collection | PubMed |
description | The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect – supercoiling of the molecule. Topoisomerases comprise a specific group of enzymes that disentangle the topological challenges associated with DNA supercoiling. They relax DNA supercoils and resolve catenanes and knots. Here, we review the catalytic cycles, evolution, diversity, and functional roles of type II topoisomerases in organisms from all domains of life, as well as viruses and other mobile genetic elements. |
format | Online Article Text |
id | pubmed-8084294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | A.I. Gordeyev |
record_format | MEDLINE/PubMed |
spelling | pubmed-80842942021-05-05 Diversity and Functions of Type II Topoisomerases Sutormin, D. A. Galivondzhyan, A. K. Polkhovskiy, A. V. Kamalyan, S. O. Severinov, K. V. Dubiley, S. A. Acta Naturae Research Article The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect – supercoiling of the molecule. Topoisomerases comprise a specific group of enzymes that disentangle the topological challenges associated with DNA supercoiling. They relax DNA supercoils and resolve catenanes and knots. Here, we review the catalytic cycles, evolution, diversity, and functional roles of type II topoisomerases in organisms from all domains of life, as well as viruses and other mobile genetic elements. A.I. Gordeyev 2021 /pmc/articles/PMC8084294/ /pubmed/33959387 http://dx.doi.org/10.32607/actanaturae.11058 Text en Copyright ® 2021 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sutormin, D. A. Galivondzhyan, A. K. Polkhovskiy, A. V. Kamalyan, S. O. Severinov, K. V. Dubiley, S. A. Diversity and Functions of Type II Topoisomerases |
title | Diversity and Functions of Type II Topoisomerases |
title_full | Diversity and Functions of Type II Topoisomerases |
title_fullStr | Diversity and Functions of Type II Topoisomerases |
title_full_unstemmed | Diversity and Functions of Type II Topoisomerases |
title_short | Diversity and Functions of Type II Topoisomerases |
title_sort | diversity and functions of type ii topoisomerases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084294/ https://www.ncbi.nlm.nih.gov/pubmed/33959387 http://dx.doi.org/10.32607/actanaturae.11058 |
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