Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets

Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are re...

Descripción completa

Detalles Bibliográficos
Autores principales: Bruter, A. V., Rodionova, M. D., Varlamova, E. A., Shtil, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084300/
https://www.ncbi.nlm.nih.gov/pubmed/33959383
http://dx.doi.org/10.32607/actanaturae.11067
_version_ 1783686129102356480
author Bruter, A. V.
Rodionova, M. D.
Varlamova, E. A.
Shtil, A. A.
author_facet Bruter, A. V.
Rodionova, M. D.
Varlamova, E. A.
Shtil, A. A.
author_sort Bruter, A. V.
collection PubMed
description Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are regarded as novel targets for pharmacological inhibition by antitumor drug candidates.
format Online
Article
Text
id pubmed-8084300
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher A.I. Gordeyev
record_format MEDLINE/PubMed
spelling pubmed-80843002021-05-05 Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets Bruter, A. V. Rodionova, M. D. Varlamova, E. A. Shtil, A. A. Acta Naturae Research Article Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are regarded as novel targets for pharmacological inhibition by antitumor drug candidates. A.I. Gordeyev 2021 /pmc/articles/PMC8084300/ /pubmed/33959383 http://dx.doi.org/10.32607/actanaturae.11067 Text en Copyright ® 2021 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bruter, A. V.
Rodionova, M. D.
Varlamova, E. A.
Shtil, A. A.
Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title_full Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title_fullStr Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title_full_unstemmed Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title_short Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets
title_sort super-enhancers in the regulation of gene transcription: general aspects and antitumor targets
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084300/
https://www.ncbi.nlm.nih.gov/pubmed/33959383
http://dx.doi.org/10.32607/actanaturae.11067
work_keys_str_mv AT bruterav superenhancersintheregulationofgenetranscriptiongeneralaspectsandantitumortargets
AT rodionovamd superenhancersintheregulationofgenetranscriptiongeneralaspectsandantitumortargets
AT varlamovaea superenhancersintheregulationofgenetranscriptiongeneralaspectsandantitumortargets
AT shtilaa superenhancersintheregulationofgenetranscriptiongeneralaspectsandantitumortargets

Ejemplares similares