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Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads

Next-generation sequencing (NGS) has transformed molecular biology and contributed to many seminal insights into genomic regulation and function. Apart from whole-genome sequencing, an NGS workflow involves alignment of the sequencing reads to the genome of study, after which the resulting alignment...

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Detalles Bibliográficos
Autores principales: Shah, Rohan N., Ruthenburg, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084338/
https://www.ncbi.nlm.nih.gov/pubmed/33872311
http://dx.doi.org/10.1371/journal.pcbi.1008926